Anti-GRID2 antibody (ab55165)

Overview

• Product nameAnti-GRID2 antibodySee all GRID2 primary antibodies ...
• Description
  Mouse monoclonal to GRID2
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Recombinant Fragment
  Predicted to work with: Human
• Immunogen

  Recombinant fragment: DTLPTRQALE QISDFRNTHI TTTTFIPEQI QTLSRTLSAK AASGFTFGNV PEHRTGPFRH RAPNGGFFRS PIKTMSSIPY QPTPTLGLNL GNDPDRGTSI , corresponding to amino acids 908-1008 of Human GRID2

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  PBS, pH 7.2
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Neuroscience
  • Neurotransmitter
  • Amino Acids
  • Glutamate

  • Neuroscience
  • Neurotransmission
  • Receptors / Channels
  • Ligand-Gated Ion Channels
  • More Channels

Applications

Target

• RelevanceGlutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. Mouse GRID2 is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.
• Cellular localizationCell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane;
• Database links
  • Entrez Gene: 2895 Human
  • Entrez Gene: 2895 Human
  • Omim: 602368 Human
  • SwissProt: O43424 Human
  • SwissProt: O43424 Human
  • Unigene: 480281 Human

• Alternative names
  GLUR D2 antibodyGluR delta 2 antibodyGLURD 2 antibody

  GLURD2 antibodyGlutamate receptor delta 2 subunit antibodyGlutamate receptor ionotropic delta 2 antibodyGRID 2 antibodyMGC117022 antibodyMGC117023 antibodyMGC117024 antibody

  see all

Anti-GRID2 antibody images

• 

  Western blot - GRID2 antibody (ab55165)
  Western blot against tagged recombinant protein immunogen using ab55165 GRID2 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

  This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.