![Western blot - GRK1 antibody [EPR2039(2)] (ab108502) image](#GRK1-Primary-antibodies-ab108502-4.jpg)
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Product name
Anti-GRK1 antibody [EPR2039(2)]
See all GRK1 products (5) ...
Description
Rabbit monoclonal [EPR2039(2)] to GRK1
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
A synthetic peptide corresponding to residues in Human GRK1.
Positive control
Y79 and JAR cell lysates.
General notes
Produced under U.S. Patent No. 5,675,063.
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purity
Tissue culture supernatant
Clonality
Monoclonal
Clone number
EPR2039(2)
Isotype
IgG1
Research areas
Neuroscience >> Sensory System >> Visual system
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Receptor Tyrosine Kinases
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> More GPCR
Neuroscience >> Neurotransmission >> Intracellular Signaling >> Kinases
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Western blot - GRK1 antibody [EPR2039(2)] (ab108502)
![Western blot - GRK1 antibody [EPR2039(2)] (ab108502) image](/ps/datasheet/images/108/ab108502/GRK1-Primary-antibodies-ab108502-4.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab108502 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/10000. Detects a band of approximately 60 kDa (predicted molecular weight: 60 kDa).
Application notes
Is unsuitable for ,Flow Cyt,ICC,IHC-P or IP.
Target
Function
Phosphorylates rhodopsin thereby initiating its deactivation. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.
Tissue specificity
Retina and pineal gland.
Involvement in disease
Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type 2 (CSNBO2) [MIM:613411]. It is non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation.
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain.
Post-translational
modifications
Autophosphorylated.
Farnesylation is required for full activity.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ15835
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- GPRK1 antibody
- G protein-coupled receptor kinase 1 antibody
- Grk1 antibody
see all
Database links
- Entrez Gene: 6011 Human
- Entrez Gene: 24013 Mouse
- Entrez Gene: 81760 Rat
- Omim: 180381 Human
- SwissProt: Q15835 Human
- SwissProt: Q9WVL4 Mouse
- SwissProt: Q63651 Rat
- Unigene: 103501 Human
see all
Anti-GRK1 antibody [EPR2039(2)] images:
Western blot - GRK1 antibody [EPR2039(2)] (ab108502)
All lanes : Anti-GRK1 antibody [EPR2039(2)] (ab108502) at 1/1000 dilution
Lane 1 : Y79 cell lysate
Lane 2 : JAR cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size : 60 kDa
Observed band size : 60 kDa
References for Anti-GRK1 antibody [EPR2039(2)] (ab108502)
ab108502 has not yet been referenced specifically in any publications.
Publishing research using ab108502? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"