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Anti-GRP78 BiP antibody [76-E6] (ab25192)

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Overview

Product name

Anti-GRP78 BiP antibody [76-E6]
See all GRP78 BiP products (13) ...

Description

Rat monoclonal [76-E6] to GRP78 BiP

Specificity

This antibody has been shown to be useful in studies of immunoglobulin assembly and secretion.

Tested applications

Functional Studies, WB, ELISAmore details

Cross reactivity

Reacts with

Mouse, Hamster

Immunogen

The details of the immunogen for this antibody are not available.

Epitope

This antibody recognizes a conserved epitope localized within the region of amino acids 497 to 581 of BiP.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

100 mM borate buffered saline, pH 8.0.

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

76-E6

Isotype

IgG1

Light chain type

kappa

Research areas

Tags & Cell Markers >> Subcellular Markers >> Organelles >> ER

Applications

Show applications key

Our Abpromise guarantee covers the use of ab25192 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    Functional Studies

     FuncS: Use at an assay d...Read more →

    FuncS: Use at an assay dependent dilution. (Immunoglobulin assembly and secretion.)

  • ShowHide

    WB

     WB: Use at an assay depe...Read more →

    WB: Use at an assay dependent dilution. Predicted molecular weight: 72 kDa.

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    ELISA

     ELISA: Use at an assay d...Read more →

    ELISA: Use at an assay dependent dilution.

Target

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Involvement in disease

Note=Autoantigen in rheumatoid arthritis.

Sequence similarities

Belongs to the heat shock protein 70 family.

Cellular localization

Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Target information above from: UniProt accessionP11021 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 78 kDa glucose regulated protein antibody
  • 78 kDa glucose-regulated protein antibody
  • BIP antibody
  • Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody
  • Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody
  • FLJ26106 antibody
  • Glucose Regulated Protein 78kDa antibody
  • GRP 78 antibody
  • GRP-78 antibody
  • GRP78 antibody
  • GRP78_HUMAN antibody
  • Heat shock 70 kDa protein 5 antibody
  • Heat Shock 70kDa Protein 5 antibody
  • HSPA 5 antibody
  • HSPA5 antibody
  • Immunoglobulin Heavy Chain Binding Protein antibody
  • Immunoglobulin heavy chain-binding protein antibody
  • MIF2 antibody
see all

Database links

References for Anti-GRP78 BiP antibody [76-E6] (ab25192)

This product has been referenced in:

  • Fausther-Bovendo Het al. HIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway. PLoS Pathog 6:e1000975 (2010). ICC/IF; Human.Read more (PubMed: 20617170) »

See 1 publication for this product

Publishing research using ab25192? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"