Potent voltage-gated TTX-sensitive Na+ and T-Type Ca2+ channel blocker
Potent voltage-gated TTX-sensitive Na+ and T-Type Ca2+ channel blocker (IC50 values are 7 and 120 nM for hNaV1.7 and hNaV1.3 respectively). Shows very little effect on TTX-resistant sodium channels. In the same family as GrTx1 (ab145540), GsAF-I (ab145541) and GsAF-II (ab145542).
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Any other aqueous buffer, pH > 8
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Kimura T et al. Molecular Cloning and Sequence Analysis of the cDNAs Encoding Toxin-Like Peptides from the Venom Glands of Tarantula Grammostola rosea. Int J Pept2012:731293 (2012).
Read more (PubMed: 22500178) »
Ono S et al. Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea. Toxicon58:265-76 (2011).
Read more (PubMed: 21740921) »