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Overview

  • Product nameGelsolin peptideSee all Gelsolin proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 750 to the C-terminus of Human Gelsolin.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab74420 - Gelsolin antibody.
  • Protein length782 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab74420.

    • Protein info

    • Alternative names
        Actin depolymerizing factorActin-depolymerizing factorADF
        AGELBrevinDKFZp313L0718GELS_HUMANGelsolinGSN
      see all
  • FunctionCalcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
  • Tissue specificityPhagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
  • Involvement in diseaseDefects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
  • Sequence similaritiesBelongs to the villin/gelsolin family.
    Contains 6 gelsolin-like repeats.
  • Post-translational
    modifications    Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
  • Cellular localizationCytoplasm > cytoskeleton and Secreted.

    • Target information above from: UniProt accession P06396 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Gelsolin peptide (ab74419)

    ab74419 has not yet been referenced specifically in any publications.

    Publishing research using ab74419 ? Please let us know so that we can cite the reference in this datasheet

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