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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger
Overview
Product name
Gli1 peptide (1009-1058)
See all Gli1 products (2) ...
Protein description
Synthetic peptide: Sequence SCGHPEVGRL GGGPALYPPP EGQVCNPLDS LDLDNTQLDF VAILDEPQGL , corresponding to C terminal amino acids 1009-1058 of Human Gli1
Protein length
49 amino acids
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Concentration
Concentration information loading...
Sequence
SCGHPEVGRL GGGPALYPPP EGQVCNPLDS LDLDNTQLDF VAILDEPQGL
Research areas
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Krueppel like factor
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> PTC & Wnt pathway
Stem Cells >> Signaling Pathways >> Hedgehog >> Nuclear
Neuroscience >> Neurology process >> Neural Signal Transduction
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger
Applications
Show applications key
Our Abpromise guarantee covers the use of ab86150 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
Application notes
BL: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Relevance
Gli1 is a member of the Kruppel family of zinc finger proteins. The Gli transcription factors constitute the final effectors of the Hedgehog signalling pathway, which is critical to vertebrate development. Gli1 may play a role in craniofacial and digital development, as well as development of the central nervous system and gastrointestinal tract. Ectopic activation of Gli proteins is linked to tumorigenesis. In addition, both the Ras and Transforming Growth Factor Beta pathways also stimulate and/or induce Gli1 and Gli2 activity independently of Hedgehog ligands.
Cellular localization
Cytoplasmic and Nuclear
References for Gli1 peptide (1009-1058) (ab86150)
ab86150 has not yet been referenced specifically in any publications.
Publishing research using ab86150? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"