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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger
Overview
Product name
Glucocorticoid Receptor alpha peptide (755-771)
Protein description
Synthetic peptide: CEIITNQIPKYSNGNIKK, corresponding to amino acids 755-771 of Human Glucocorticoid Receptor alpha
Properties
Purity
>90% by SDS-PAGE
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Double distilled water.
Concentration
Concentration information loading...
Sequence
CEIITNQIPK YSNGNIKK
Applications
Show applications key
Our Abpromise guarantee covers the use of ab39764 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Neutralising
Application notes
Neut: Use at an assay dependent dilution.
This peptide can be used with studies using ab3580.
Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Relevance
Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism and the immune and inflammatory responses. These compounds exert their effect through their interaction with the Glucocorticoid Receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform translocates from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR alpha has a greater affinity for GR response elements (GREs) than GR beta only when in the ligand bound state.
Cellular localization
Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand; nuclear after ligand-binding.
References for Glucocorticoid Receptor alpha peptide (755-771) (ab39764)
ab39764 has not yet been referenced specifically in any publications.
Publishing research using ab39764? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"