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Anti-Glucocorticoid receptor-interacting protein 1 antibody
See all KAT13C / NCOA2 products (11) ...
Rabbit polyclonal to Glucocorticoid receptor-interacting protein 1
IHC-Frmore details
Reacts with
Hamster, Human
Predicted to work with
Mouse, Rat
Synthetic peptide: PLPDSEEEGHDS-C, corresponding to amino acids 206-217 of Human GRIP1 (Peptide available as ab4917.)
PLPDSEEEGH DS-C
CHO cells
Liquid
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS, 1 mg/ml BSA, 0.05% sodium azide
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IgG fraction
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Glucocorticoid receptor interacting protein-1 (GRIP 1), or Transcription Intermediary Factor 2 (TIF 2), is a member of a family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC 1) and Amplified in breast cancer-1 (AIB 1). GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP 1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.
Polyclonal
IgG
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Epigenetics and Nuclear Signaling >> Transcription >> Mediator Complex
Epigenetics and Nuclear Signaling >> Transcription >> Co-factors
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors
Neuroscience >> Neurology process >> Neural Signal Transduction
Cell Biology >> Apoptosis >> Nucleus >> Other
Our Abpromise guarantee covers the use of ab2842 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Immunohistochemistry: 1/1000 dilution on CHO cells shows cytoplasmic and nuclear staining.
This antibody has not been used successfully in Western blot procedures.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is KAT13C / nuclear receptor coactivator 2 (NCOA2), also termed Glucocorticoid receptor-interacting protein 1 (GRIP1).
Nuclear
ab2842 has not yet been referenced specifically in any publications.
Publishing research using ab2842? Please let us know so that we can cite the reference in this datasheet
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