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Product Name
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Glucocorticoid receptor-interacting protein 1 antibody
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See all KAT13C / NCOA2 antibodies (10)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Glucocorticoid receptor-interacting protein 1
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Immunogen
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Synthetic peptide: PLPDSEEEGHDS-C, corresponding to amino acids 206-217 of Human GRIP1
(Peptide available as ab4917.)
BLAST 'PLPDSEEEGHDS-C' with  or 
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Reacts with
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Hu, Hm
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Predicted to react
(species key)
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Ms, Rat
(Due to sequence homology)
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Tested applications
(see key)
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IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Immunohistochemistry: 1/1000 dilution on CHO cells shows cytoplasmic and nuclear staining.
This antibody has not been used successfully in Western blot procedures.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
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Positive control
(see definition)
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CHO cells
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Cellular localization
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Nuclear
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Chromatin and Nuclear Signaling >> Transcription >> Mediator Complex
Chromatin and Nuclear Signaling >> Transcription >> Co-factors
Chromatin and Nuclear Signaling >> Transcription >> Other factors
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors
Neuroscience >> Neurology process >> Neural Signal Transduction
Cell Biology >> Apoptosis >> Nucleus >> Other
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Relevance
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Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcriptional activity of the nuclear receptor with which they associate. One such coactivator is KAT13C / nuclear receptor coactivator 2 (NCOA2), also termed Glucocorticoid receptor-interacting protein 1 (GRIP1).
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Glucocorticoid receptor interacting protein-1 (GRIP 1), or Transcription Intermediary Factor 2 (TIF 2), is a member of a family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC 1) and Amplified in breast cancer-1 (AIB 1).
GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP 1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.
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Glucocorticoid receptor-interacting protein 1 antibody (ab2842) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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IgG fraction
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Storage buffer
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PBS, 1 mg/ml BSA, 0.05% sodium azide Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Glucocorticoid receptor-interacting protein 1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to KAT13C / NCOA2
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Glucocorticoid receptor-interacting protein 1 antibody - more information
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