Anti-Glucocorticoid receptor-interacting protein 1 antibody (ab2842)

Product name

Anti-Glucocorticoid receptor-interacting protein 1 antibody
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Description

Rabbit polyclonal to Glucocorticoid receptor-interacting protein 1

Tested applications

IHC-Frmore details

Cross reactivity

Reacts with

Hamster, Human

Predicted to work with

Mouse, Rat

Immunogen

Synthetic peptide: PLPDSEEEGHDS-C, corresponding to amino acids 206-217 of Human GRIP1 (Peptide available as ab4917.)

PLPDSEEEGH DS-C

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Positive control

CHO cells

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS, 1 mg/ml BSA, 0.05% sodium azide

Concentration

Concentration information loading...

Purity

IgG fraction

Primary antibody notes

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Glucocorticoid receptor interacting protein-1 (GRIP 1), or Transcription Intermediary Factor 2 (TIF 2), is a member of a family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC 1) and Amplified in breast cancer-1 (AIB 1). GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP 1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.

Clonality

Polyclonal

Isotype

IgG

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Epigenetics and Nuclear Signaling >> Transcription >> Mediator Complex
Epigenetics and Nuclear Signaling >> Transcription >> Co-factors
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Co-activators/co-repressors

Neuroscience >> Neurology process >> Neural Signal Transduction
Cell Biology >> Apoptosis >> Nucleus >> Other