Anti-Glucose 6 phosphate isomerase antibody (ab81466)

Overview

• Product nameAnti-Glucose 6 phosphate isomerase antibodySee all Glucose 6 phosphate isomerase primary antibodies ...
• Description
  Rabbit polyclonal to Glucose 6 phosphate isomerase
• Tested applicationsIHC-P, IHC-Fr, WB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide derived from an internal domain of human Glucose 6 phosphate isomerase.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: Whole serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Carbohydrate metabolism

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of carbohydrates

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Immunology
  • Immune System Diseases
  • Autoimmune

  • Neuroscience
  • Neurology process
  • Growth and Development
  • Neurotrophins

Applications

Target

• FunctionBesides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.
• PathwayCarbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
• Involvement in diseaseDefects in GPI are the cause of hemolytic anemia non-spherocytic due to glucose phosphate isomerase deficiency (HA-GPID) [MIM:613470]. It is a form of anemia in which there is no abnormal hemoglobin or spherocytosis. It is caused by glucose phosphate isomerase deficiency. Severe GPI deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
• Sequence similaritiesBelongs to the GPI family.
• Post-translational
  modificationsPhosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway.
  ISGylated.
• Cellular localizationCytoplasm. Secreted.

Target information above from: UniProt accession P06744 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 2821 Human
  • Entrez Gene: 14751 Mouse
  • Entrez Gene: 292804 Rat
  • Omim: 172400 Human
  • SwissProt: P06744 Human
  • SwissProt: P06745 Mouse
  • SwissProt: Q6P6V0 Rat
  • Unigene: 466471 Human

  • Unigene: 589 Mouse
  • Unigene: 84435 Rat

  see all

• Alternative names
  AMF antibodyAurocrine motility factor antibodyAutocrine motility factor antibody

  DKFZp686C13233 antibodyEC 5.3.1.9 antibodyG6PI_HUMAN antibodyGlucose phosphate isomerase antibodyGlucose-6-phosphate isomerase antibodyGNPI antibodyGPI antibodyGpi1 antibodyHexose monophosphate isomerase antibodyHexosephosphate isomerase antibodyNeuroleukin antibodyNLK antibodyOxoisomerase antibodyPGI antibodyPHI antibodyPhosphoglucose isomerase antibodyPhosphohexomutase antibodyPhosphohexose isomerase antibodyPhosphosaccharomutase antibodySA 36 antibodySA-36 antibodySA36 antibodySperm antigen 36 antibody

  see all