Anti-Glucose Transporter GLUT1 antibody [SPM498] - Carboxyterminal end, prediluted (ab53654)

Overview

• Product nameAnti-Glucose Transporter GLUT1 antibody [SPM498] - Carboxyterminal end, predilutedSee all Glucose Transporter GLUT1 primary antibodies ...
• Description
  Mouse monoclonal [SPM498] to Glucose Transporter GLUT1 - Carboxyterminal end, prediluted
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Synthetic peptide derived from C-terminal of human Glucose Transporter GLUT1 protein.

• Epitopeab53654 recognises an epitope located in the C terminal region of Glucose Transporter GLUT1.
• Positive controlHepG2 cells. Esophagous and breast carcinoma.

Properties

• FormLiquid
• Storage instructionsStore at +4°C.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: 1% BSA, 50mM Tris, pH 7.6
• Concentration information loading...
• Clonality Monoclonal
• Clone numberSPM498
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Metabolism
  • Types of disease
  • Diabetes

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Types of disease
  • Heart disease

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Carbohydrate metabolism

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Metabolism of carbohydrates

  • Signal Transduction
  • Metabolism
  • Plasma Membrane
  • Channels

  • Cardiovascular
  • Atherosclerosis
  • Diabetes associated

Applications

Target

• FunctionFacilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
• Tissue specificityExpressed at variable levels in many human tissues.
• Involvement in diseaseDefects in SLC2A1 are the cause of glucose transporter type 1 deficiency syndrome (GLUT1DS) [MIM:606777]; also known as blood-brain barrier glucose transport defect. This disease causes a defect in glucose transport across the blood-brain barrier. It is characterized by infantile seizures, delayed development, and acquired microcephaly.
  Defects in SLC2A1 are the cause of dystonia type 18 (DYT18) [MIM:612126]. DYT18 is an exercise-induced paroxysmal dystonia/dyskinesia. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT18 is characterized by attacks of involuntary movements triggered by certain stimuli such as sudden movement or prolonged exercise. In some patients involuntary exertion-induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia.
• Sequence similaritiesBelongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
• Post-translational
  modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
• Cellular localizationCell membrane. Melanosome. Localizes primarily at the cell surface (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Target information above from: UniProt accession P11166 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 6513 Human
  • Entrez Gene: 20525 Mouse
  • Entrez Gene: 24778 Rat
  • Omim: 138140 Human
  • SwissProt: P11166 Human
  • SwissProt: P17809 Mouse
  • SwissProt: P11167 Rat
  • Unigene: 473721 Human

  • Unigene: 721551 Human
  • Unigene: 21002 Mouse
  • Unigene: 3205 Rat

  see all

• Alternative names
  DYT17 antibodyDYT18 antibodyerythrocyte/brain antibody

  Erythrocyte/brain HepG2 glucose transporter antibodyErythrocyte/hepatoma glucose transporter antibodyfacilitated glucose transporter member 1 antibodyGlucose transporter 1 antibodyGlucose transporter type 1 antibodyGlucose transporter type 1 erythrocyte/brain antibodyGlucose transporter type 1, erythrocyte/brain antibodyGLUT antibodyGLUT-1 antibodyGLUT1 antibodyGLUT1DS antibodyGLUTB antibodyGT1 antibodyGTG1 antibodyGtg3 antibodyGTR1_HUMAN antibodyHepG2 glucose transporter antibodyMGC141895 antibodyMGC141896 antibodyPED antibodyRATGTG1 antibodySLC2A 1 antibodySLC2A1 antibodySolute carrier family 2 (facilitated glucose transporter), member 1 antibodySolute carrier family 2 antibodySolute carrier family 2 facilitated glucose transporter member 1 antibodySolute carrier family 2, facilitated glucose transporter member 1 antibody

  see all

Anti-Glucose Transporter GLUT1 antibody [SPM498] - Carboxyterminal end, prediluted images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Glucose Transporter GLUT1 antibody [SPM498], prediluted (ab53654)
  ab53654 (pre-diluted) staining Glucose Transporter GLUT1 in human esophagous by Immunohistochemsitry, Formalin-fixed, Parafin embedded tissue.