Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Related products
- Secondary antibodies
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-GnRH antibody - N-terminal
See all GnRH products (10) ...
Description
Rabbit polyclonal to GnRH - N-terminal
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
KLH conjugated synthetic peptide selected from the N terminal region of human GnRH.
Positive control
Human brain tissue
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Ammonium Sulphate Precipitation
Purification notes
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Clonality
Polyclonal
Isotype
IgG
Research areas
Developmental Biology >> Reproduction >> Hormones
Signal Transduction >> Growth Factors/Hormones >> Hormones
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GnRH antibody - N-terminal (ab80001)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab80001 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/10 - 1/50.
Target
Relevance
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
Cellular localization
Secreted
Alternative names
- GNRH1 antibody
- Gonadotrophin releasing hormone 1 antibody
- GRH antibody
see all
Database links
- Entrez Gene: 2796 Human
- Omim: 152760 Human
- SwissProt: P01148 Human
Anti-GnRH antibody - N-terminal images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - GnRH antibody - N-terminal (ab80001)
Formalin-fixed and paraffin-embedded human brain tissue reacted with ab80001 at a 1/10-1/50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
References for Anti-GnRH antibody - N-terminal (ab80001)
ab80001 has not yet been referenced specifically in any publications.
Publishing research using ab80001? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"