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Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-GnRH antibody
See all GnRH products (10) ...
Description
Rabbit polyclonal to GnRH
Tested applications
IHC-P, IF, IHC-FoFr, IHC-Frmore details
Cross reactivity
Reacts with
Mouse, Human
Predicted to work with
Rat, Sheep, Hamster, Pig, Xenopus laevis, Rhesus monkey
Immunogen
Positive control
Mouse brain tissue sections.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purification notes
Purified via ammonium sulfate precipitation.
Clonality
Polyclonal
Isotype
IgG
Research areas
Developmental Biology >> Reproduction >> Hormones
Signal Transduction >> Growth Factors/Hormones >> Hormones
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- GnRH antibody (ab5617)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab5617 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution. (PubMed: 20940512)
IF
IF: 1/1000IF: 1/1000
IHC-FoFr
IHC-FoFr: 1/500IHC-FoFr: 1/500
IHC-Fr: 1/5000(4% paraformaldehyde is recommended as a fixative.)
Target
Relevance
Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle. Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.
Cellular localization
Secreted
Alternative names
- GNRH 1 antibody
- GNRH1 antibody
- Gonadotrophin Releasing Hormone 1 antibody
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Database links
- Entrez Gene: 2796 Human
- Entrez Gene: 14714 Mouse
- Entrez Gene: 25194 Rat
- Omim: 152760 Human
- SwissProt: P01148 Human
- SwissProt: P13562 Mouse
- SwissProt: P49921 Pig
- SwissProt: P07490 Rat
see all
Anti-GnRH antibody images:
- GnRH antibody (ab5617)
Immunolocalization of GnRH in mouse embryo forebrain using ab5617 at a 1/1000 dilution.
References for Anti-GnRH antibody (ab5617)
This product has been referenced in:
- Layman WSet al. Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome. Hum Mol Genet : (2011).Read more (PubMed: 21596839) »
- Teixeira Let al. Defective migration of neuroendocrine GnRH cells in human arrhinencephalic conditions. J Clin Invest 120:3668-72 (2010). IHC-P; Human.Read more (PubMed: 20940512) »
See all 6 publications for this product
Publishing research using ab5617? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"