Overview

  • Product nameAnti-Granzyme B antibody [GZB01]
    See all Granzyme B primary antibodies
  • Description
    Mouse monoclonal [GZB01] to Granzyme B
  • SpecificityThis antibody reacts with a 32 kD protein.
  • Tested applicationsIHC-P, IHC-Fr, WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human).

  • Positive control
    • IHC: Hodgkin’s lymphoma. WB: human lymphoid cell extract

Properties

Applications

Our Abpromise guarantee covers the use of ab3654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/25. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
IHC-Fr 1/10 - 1/25.
WB 1/100 - 1/250. Detects a band of approximately 32 kDa (predicted molecular weight: 32 kDa).
IP 1/100 - 1/250.

Target

  • FunctionThis enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
  • Sequence similaritiesBelongs to the peptidase S1 family. Granzyme subfamily.
    Contains 1 peptidase S1 domain.
  • Cellular localizationCytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • C11 antibody
    • Cathepsin G like 1 antibody
    • Cathepsin G-like 1 antibody
    • Cathespin G Like 1 antibody
    • CCPI antibody
    • CGL 1 antibody
    • CGL1 antibody
    • CSP B antibody
    • CSPB antibody
    • CTLA 1 antibody
    • CTLA-1 antibody
    • CTLA1 antibody
    • CTSGL 1 antibody
    • CTSGL1 antibody
    • Cytotoxic serine protease B antibody
    • Cytotoxic T Lymphocyte Associated Serine Esterase 1 antibody
    • Cytotoxic T lymphocyte proteinase 2 antibody
    • Cytotoxic T-lymphocyte proteinase 2 antibody
    • Fragmentin 2 antibody
    • Fragmentin-2 antibody
    • Fragmentin2 antibody
    • GRAB_HUMAN antibody
    • Granzyme 2 antibody
    • Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody
    • Granzyme B antibody
    • Granzyme-2 antibody
    • Granzyme2 antibody
    • GranzymeB antibody
    • GRB antibody
    • GZMB antibody
    • HLP antibody
    • HLP antibody
    • Human lymphocyte protein antibody
    • Lymphocyte protease antibody
    • Protease Serine B antibody
    • Protease, serine, B antibody
    • SECT antibody
    • T cell serine protease 1 3E antibody
    • T cell serine protease 1-3E antibody
    • T-cell serine protease 1-3E antibody
    see all

Anti-Granzyme B antibody [GZB01] images

  • ab3654 - immunohistochemistry

    Formalin fixed paraffin embedded human Hodgkin's lymphoma with EBV stained with Granzyme B using ABC and AEC chromagen.

References for Anti-Granzyme B antibody [GZB01] (ab3654)

ab3654 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"