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Overview

  • Product nameGrowth Hormone Human ELISA KitSee all Human Growth Hormone kits ...
  • Tests
    1 x 96 well plate
  • Sample type
    Serum
  • Assay typeSandwich
  • Sensitivity
    = 0.5 ng/ml
  • Range
    0.5 ng/ml - 50 ng/ml
  • Species reactivity
    Reacts with: Human
  • Product overview

    ab108643 Human Growth Hormone Human ELISA Kit is intended for the quantitative determination of the Human Growth Hormone (HGH) concentration in human serum.

    Human Growth Hormone (HGH, somatotropin) is a polypeptide secreted by the anterior pituitary. It is 191 amino acids in length and has a molecular mass of approximately 22,000 daltons. Its metabolic effects are primarily anabolic. Human Growth Hormone promotes protein conservation and is engaged in a wide range of mechanisms for protein synthesis. It also enhances glucose transport and facilitates glycogen storage. Its cascade of growth-promoting action is mediated by another family of peptide hormones, the somatomedins. Human Growth Hormone measurement is primarily of interest in the diagnosis and treatment of various forms of abnormal growth hormone secretion. Disorders caused by hyposecretion include dwarfism and unattained growth potential, and hypersecretion is associated with gigantism and acromegaly.

  • Tested applicationsELISA more details

Properties

  • FunctionPlays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
  • Involvement in diseaseDefects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH.
    Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH.
    Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI.
    Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
  • Sequence similaritiesBelongs to the somatotropin/prolactin family.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P01241 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
    • Alternative names
        gHGH-NGH1
        GHNGrowth hormoneGrowth hormone 1HGHPituitary growth hormoneSOMA_HUMANSomatotropin
      see all
  • Database links

      • Applications

      Our Abpromise guarantee covers the use of ab108643 in the following tested applications.

      The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

      Application Notes
      ELISA ELISA

      Growth Hormone Human ELISA Kit images

      • ELISA - Human Growth Hormone Human ELISA Kit (ab108643)
        ELISA - Human Growth Hormone Human ELISA Kit (ab108643)
        Human Growth Hormone Standard curve

      Protocols

      References for Growth Hormone Human ELISA Kit (ab108643)

      ab108643 has not yet been referenced specifically in any publications.

      Publishing research using ab108643 ? Please let us know so that we can cite the reference in this datasheet

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      Submit an Abreview for ab108643 Submit a Question for ab108643

      Displaying 1 - 3 of 3 results for Abreviews and Q&A

      10
      Votes: Highest First

      I know your protocol says "serum without additives," is it ok to collect blood in tubes with clot promotion factors in it or should i use simple plastic tubes?

      Thank you for your message and inquiry. The HGH ELISA has been validated using serum without additives. We have not tested the kit using additives and cannot guarantee that it would be compatible with the assay.

      SPECIMEN COLLECTION AND PREPARATIO...

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      I have a couple of question for you.

      1.- Is this liquid matrix for the standards plasma or serum?

      2.- Can you tell us the International units conversion factor for this hGH?

      Thank you for your reply.

      The liquid matrix is serum and the conversion factor for HGH is 1 ng is about 2.2 uIU.

      I hope this information helps. Please contact us with any other questions.

      I bought this kit, but the standards are in liquid form, not lyophilized.

      Thank you for your inquiry and your patience with this reply as I was awaiting more information from the lab.

      The kit was recently changed to include the standards in liquid form. We are currently updating the product insert, which will be avai...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"