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Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-H6PD antibody
See all H6PD products (4) ...
Description
Rabbit polyclonal to H6PD
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Cow
Immunogen
Synthetic peptide, corresponding to a region within N terminal amino acids 179-228 (HFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFR DQNRKALDGLW) of Human H6PD NP_0042760
Positive control
721_B cell lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 2% Sucrose, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurology process >> Metabolism
Signal Transduction >> Metabolism >> Energy Metabolism
Signal Transduction >> Growth Factors/Hormones >> Hormones
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Western blot - H6PD antibody (ab84353)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab84353 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlDetects a band of approximately 89 kDa (predicted molecular weight: 89 kDa).
Target
Function
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Tissue specificity
Present in most tissues examined, strongest in liver.
Involvement in disease
Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Sequence similarities
In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.
In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
Cellular localization
Endoplasmic reticulum lumen. Microsomes, endoplasmic reticulum lumen.
Target information above from: UniProt accessionO95479
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 6 phosphogluconolactonase antibody
- 6-phosphogluconolactonase antibody
- 6PGL antibody
see all
Database links
- Entrez Gene: 25796 Human
- Entrez Gene: 9563 Human
- Entrez Gene: 100198 Mouse
- Entrez Gene: 66171 Mouse
- Entrez Gene: 298655 Rat
- Omim: 138090 Human
- SwissProt: O95336 Human
- SwissProt: O95479 Human
see all
Anti-H6PD antibody images:
Western blot - H6PD antibody (ab84353)
Anti-H6PD antibody (ab84353) at 1 µg/ml + 721_B cell lysate at 10 µg
Secondary
anti-Rabbit IgG HRP at 1/50000 dilution
Predicted band size : 89 kDa
Observed band size : 89 kDa
Additional bands at : 42 kDa,65 kDa. We are unsure as to the identity of these extra bands.
References for Anti-H6PD antibody (ab84353)
ab84353 has not yet been referenced specifically in any publications.
Publishing research using ab84353? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"