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H89 dihydrochloride

Product code: ab120341 (formerly Asc-341)

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Overview

Product name

H89 dihydrochloride

Description

Kinase inhibitor

Biological description

Kinase inhibitor, commonly used as a protein kinase A inhibitor (IC50 = 135 nM). Also inhibits other kinases, including MSK1 , S6K1 and ROCKII (IC50 values are 120 nM, 80 nM and 270 nM respectively).

Purity

> 98%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

N-[2-[[3-(4-Bromophenyl)-2-propen-1-yl]amino]ethyl]-5-Isoquinolinesulfonamide dihydrochloride

Molecular Weight

519.28

Chemical structure

Chemical Structure

Molecular formula

C20H20BrN3O2S.HCl

CAS Number

127243-85-0

Solubility

Soluble in water to 25 mM and in DMSO to 100 mM

PubChem identifier

0

Storage instructions

Store at -20°C (desiccating conditions).

Research areas

Biochemicals >> Research Area >> Stroke >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Inositol & cAMP signaling >> Protein Kinase A >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Protein Kinase A >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> General >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals

References for H89 dihydrochloride (ab120341)

This product has been referenced in:

See all 2 publications for this product

Publishing research using ab120341? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"