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Product name
HA-1077
Description
ROCK2 inhibitor
Alternative names
- Fasudil
Biological description
ROCK2 inhibitor with some actions on PRK2 and MSK1 ( IC50 values are 1.9 μM, 4 μM and 5 μM respectively) Also shown to inhibit RSK1, RSK2, PKA , AMPK and PKd1. Calcium channel antagonist and vasodilator.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
1-(5-Isoquinolinylsulfonyl)homopiperazine hydrochloride
Molecular Weight
327.83
Chemical structure
Molecular formula
C14H17N3O2S.HCl
CAS Number
103745-39-7
Solubility
Soluble in water to 100 mM
Storage instructions
Store at room temperature.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Rho kinase >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> General >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
Biochemicals >> Product Range >> Just Add Water
References for HA-1077 (ab120306)
This product has been referenced in:
- Bain J et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007).Read more (PubMed: 17850214) »
- Davies SP et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105 (2000).Read more (PubMed: 10998351) »
See all 4 publications for this product
Publishing research using ab120306? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"