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Products:Cardiovascular >> Blood >> Serum Proteins
Overview
Product name
Anti-HABP2 antibody
See all HABP2 products (2) ...
Description
Mouse monoclonal to HABP2
Tested applications
ELISAmore details
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Human
Immunogen
Recombinant fragment: GNKCQKVQNT CKDNPCGRGQ CLITQSPPYY RCVCKHPYTG PSCSQVVPVC RPNPCQNGAT CSRHKRRSKF TCACPDQFKG KFCEIGSDDC YVGDGYSYRG , corresponding to amino acids 105-205 of Human HABP2
GNKCQKVQNT CKDNPCGRGQ CLITQSPPYY RCVCKHPYTG PSCSQVVPVC RPNPCQNGAT CSRHKRRSKF TCACPDQFKG KFCEIGSDDC YVGDGYSYRG
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
-
ELISA - HABP2 antibody (ab55229)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab55229 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
Target
Function
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.
Tissue specificity
Ubiquitously expressed.
Sequence similarities
Belongs to the peptidase S1 family.
Contains 3 EGF-like domains.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain.
Post-translational
modifications
Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments.
Cellular localization
Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Target information above from: UniProt accessionQ14520
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Factor seven activating protease antibody
- Factor seven-activating protease antibody
- Factor VII activating protein antibody
see all
Database links
- Entrez Gene: 3026 Human
- Omim: 603924 Human
- SwissProt: Q14520 Human
- Unigene: 422542 Human
Anti-HABP2 antibody images:
ELISA - HABP2 antibody (ab55229)
ab55229, staining HABP2 by Elisa. The detection limit for recombinant tagged HABP2 is approximately 1ng/ml as a capture antibody.
References for Anti-HABP2 antibody (ab55229)
ab55229 has not yet been referenced specifically in any publications.
Publishing research using ab55229? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"