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Anti-HADHA/HADHB antibody [4A8BG12 ] (ab110302)

MSCatalog No. MS734

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Overview

Product name

Anti-HADHA/HADHB antibody [4A8BG12 ]

Description

Mouse monoclonal [4A8BG12 ] to HADHA/HADHB

Tested applications

ICC, IHC-P, Flow Cyt, IPmore details

Cross reactivity

Reacts with

Rat, Cow, Human

Immunogen

Human heart mitochondria

Positive control

HDFn and HL60 cells; HepG2 cell lysate; Human cerebellum tissue.

Properties

Form

Liquid

Storage instructions

Store at +4°C. Do not freeze.

Storage buffer

Preservative: 0.02% Sodium azide
Constituent: HBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Purification notes

ab110302 was produced in vitro using hybridomas grown in serum-free medium, and then purified by affinity purification.

Clonality

Monoclonal

Clone number

4A8BG12

Isotype

IgG1

Light chain type

kappa

Research areas

Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Lipid and lipoprotein metabolism >> Fatty acids
Cardiovascular >> Lipids / Lipoproteins >> Fatty Acids >> Metabolism
Signal Transduction >> Metabolism >> Lipid metabolism

  • Immunocytochemistry - HADHA/HADHB antibody [4A8BG12 ] (ab110302)Immunocytochemistry - HADHA/HADHB antibody [4A8BG12 ] (ab110302) image (enlarge)

  • Flow Cytometry - HADHA/HADHB antibody [4A8BG12 ] (ab110302)Flow Cytometry - HADHA/HADHB antibody [4A8BG12 ] (ab110302) image (enlarge)

  • Immunoprecipitation - HADHA/HADHB antibody [4A8BG12 ] (ab110302)Immunoprecipitation - HADHA/HADHB antibody [4A8BG12 ] (ab110302) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab110302 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Involvement in disease

Defects in HADHB are a cause of trifunctional protein deficiency (TFP deficiency) [MIM:609015]. The clinical manifestations are very variable and include hypoglycemia, cardiomyopathy and sudden death. Phenotypes with mainly hepatic and neuromyopathic involvement can also be distinguished. Biochemically, TFP deficiency is defined by the loss of all three enzyme activities of the TFP complex.

Sequence similarities

Belongs to the thiolase family.

Cellular localization

Mitochondrion.

Target information above from: UniProt accessionP55084 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • ECHB antibody
  • LCEH antibody
  • LCHAD antibody
  • MGC1728 antibody
  • MTPA antibody
  • TP ALPHA antibody
  • 3-ketoacyl-CoA thiolase antibody
  • 4930479F15Rik antibody
  • Acetyl-CoA acyltransferase antibody
  • Beta-ketothiolase antibody
  • C77020 antibody
  • ECHA antibody
  • ECHB_HUMAN antibody
  • GBP antibody
  • HADH antibody
  • Hadhb antibody
  • MGC105338 antibody
  • MGC87480 antibody
  • MS734 antibody
  • MSTP029 antibody
  • MTPB antibody
  • RGD1560655 antibody
  • TP-beta antibody
  • Trifunctional enzyme subunit alpha, mitochondrial antibody
see all

Database links

see all

Anti-HADHA/HADHB antibody [4A8BG12 ] images:

  Immunocytochemistry - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Immunocytochemistry - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Immunocytochemistry analysis using ab110302 at 5µg/ml staining HADHA/HADHB in HDFn cells.

  Flow Cytometry - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Flow Cytometry - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Flow cytometric analysis using ab110302 at 1µg/ml staining HADHA/HADHB in HL60 cells (blue). Isotype control antibody (red).

  Immunoprecipitation - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Immunoprecipitation - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Detection of ab110302 by Western Blot of Immunprecipitate.
Staining of HADHA/HADHB in 1 mg HepG2 cell lysate/10ul antibody conjugated beads immunoprecipitated using ab110302.

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HADHA/HADHB antibody [4A8BG12 ] (ab110302)

Immunohistochemistry analysis using ab110302 staining HADHA/HADHB in Human cerebellum Formalin-fixed, Paraffin-embedded tissue.

References for Anti-HADHA/HADHB antibody [4A8BG12 ] (ab110302)

ab110302 has not yet been referenced specifically in any publications.

Publishing research using ab110302? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"