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Overview

  • Product nameAnti-HADHSC antibody - Azide freeSee all HADHSC primary antibodies ...
  • Description
    Chicken polyclonal to HADHSC - Azide free
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Amino acids 57-314 of HADHSC

Properties

Applications

Our Abpromise guarantee covers the use of ab37673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/2000. Predicted molecular weight: 35 kDa.

Target

  • FunctionPlays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
  • Tissue specificityExpressed in liver, kidney, pancreas, heart and skeletal muscle.
  • PathwayLipid metabolism; fatty acid beta-oxidation.
  • Involvement in diseaseDefects in HADH are the cause of 3-alpha-hydroxyacyl-CoA dehydrogenase deficiency (HADH deficiency) [MIM:231530]. HADH deficiency is a metabolic disorder with various clinical presentations including hypoglycemia, hepatoencephalopathy, myopathy or cardiomyopathy, and in some cases sudden death.
    Defects in HADH are the cause of familial hyperinsulinemic hypoglycemia type 4 (HHF4) [MIM:609975]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. HHF4 should be easily recognizable by analysis of acylcarnitine species and that this disorder responds well to treatment with diazoxide. It provides the first 'experiment of nature' that links impaired fatty acid oxidation to hyperinsulinism and that provides support for the concept that a lipid signaling pathway is implicated in the control of insulin secretion.
  • Sequence similaritiesBelongs to the 3-hydroxyacyl-CoA dehydrogenase family.
  • Cellular localizationMitochondrion matrix.

    • Target information above from: UniProt accession Q16836 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      HAD antibodyHADH antibodyHADH1 antibody
      HADHSC antibodyHCDH antibodyHCDH_HUMAN antibodyHHF4 antibodyHydroxyacyl CoA dehydrogenase antibodyHydroxyacyl-coenzyme A dehydrogenase antibodyhydroxyacyl-coenzyme A dehydrogenase, mitochondrial antibodyL 3 hydroxyacyl Coenzyme A dehydrogenase short chain antibodyM SCHAD antibodyMedium and short chain L 3 hydroxyacyl coenzyme A dehydrogenase antibodyMedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase antibodyMGC8392 antibodymitochondrial antibodyMSCHAD antibodyOTTHUMP00000162626 antibodyOTTHUMP00000219688 antibodySCHAD antibodyShort chain 3 hydroxyacyl CoA dehydrogenase mitochondrial antibodyshort chain 3-hydroxyacyl-coa dehydrogenase antibodyShort-chain 3-hydroxyacyl-CoA dehydrogenase antibody
    see all

Anti-HADHSC antibody - Azide free images

References for Anti-HADHSC antibody - Azide free (ab37673)

This product has been referenced in:
  • Philp A  et al. The PGC-1a-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes. Am J Physiol Regul Integr Comp Physiol 301:R864-72 (2011). WB ; Mouse . Read more (PubMed: 21795630) »
  • Schulz N  et al. Role of Medium- and Short-Chain L-3-Hydroxyacyl-CoA Dehydrogenase in the Regulation of Body Weight and Thermogenesis. Endocrinology 152:4641-51 (2011). Read more (PubMed: 21990309) »

See all 5 Publications for this product

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