HADHSC protein (T7 Tag) (ab40712)
Constituents: 0.1% Triton-X-100, 10mM Tris, pH 8.0
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Our Abpromise guarantee covers the use of ab40712 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
SDS-PAGE: Use at an assay dependent dilution.
This protein can be used with studies using ab37673.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- HADHSCHCDHHCDH_HUMANHHF4Hydroxyacyl CoA dehydrogenaseHydroxyacyl-coenzyme A dehydrogenasehydroxyacyl-coenzyme A dehydrogenase, mitochondrialL 3 hydroxyacyl Coenzyme A dehydrogenase short chainM SCHADMedium and short chain L 3 hydroxyacyl coenzyme A dehydrogenaseMedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseMGC8392mitochondrialMSCHADOTTHUMP00000162626OTTHUMP00000219688SCHADShort chain 3 hydroxyacyl CoA dehydrogenase mitochondrialshort chain 3-hydroxyacyl-coa dehydrogenaseShort-chain 3-hydroxyacyl-CoA dehydrogenase
Defects in HADH are the cause of familial hyperinsulinemic hypoglycemia type 4 (HHF4) [MIM:609975]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy and is due to defective negative feedback regulation of insulin secretion by low glucose levels. It causes nesidioblastosis, a diffuse abnormality of the pancreas in which there is extensive, often disorganized formation of new islets. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur. HHF4 should be easily recognizable by analysis of acylcarnitine species and that this disorder responds well to treatment with diazoxide. It provides the first 'experiment of nature' that links impaired fatty acid oxidation to hyperinsulinism and that provides support for the concept that a lipid signaling pathway is implicated in the control of insulin secretion.
HADHSC protein (T7 Tag) images
SDS: Analysis of HADHSC Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining. ( HADHSC protein )
References for HADHSC protein (T7 Tag) (ab40712)
ab40712 has not yet been referenced specifically in any publications.