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Anti-HAND2 antibody (ab10131)

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Overview

Product name

Anti-HAND2 antibody
See all HAND2 products (3) ...

Description

Rabbit polyclonal to HAND2

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat, Chicken, Zebrafish

Immunogen

Synthetic peptide conjugated to KLH, corresponding to a region between amino acids 190-204 of Human HAND2.

Positive control

HeLa whole cell lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS, Sucrose

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - HAND2 antibody (ab10131)Western blot - HAND2 antibody (ab10131) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab10131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: 1/1000. Detects a band of approximately 24 kDa (predicted molecular weight: 26 kDa).
ELISA: positive result with immunising peptide.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.

Tissue specificity

Heart.

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

Developmental stage

Expressed in the fetal heart.

Cellular localization

Nucleus.

Target information above from: UniProt accessionP61296 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • autonomic nervous system and neural crest derivatives-expressed protein 2 antibody
  • heart antibody
  • AI225906 antibody
  • AI661148 antibody
  • Basic helix loop helix transcription factor HAND2 antibody
  • bHLHa26 antibody
  • Class A basic helix-loop-helix protein 26 antibody
  • Deciduum antibody
  • Deciduum heart autonomic nervous system and neural crest derivatives expressed protein 2 antibody
  • DHAND 2 antibody
  • DHAND antibody
  • DHAND2 antibody
  • Ehand 2 antibody
  • Ehand2 antibody
  • FLJ16260 antibody
  • HAND 2 antibody
  • Hand2 antibody
  • HAND2_HUMAN antibody
  • Heart and neural crest derivatives expressed 2 antibody
  • Heart and neural crest derivatives expressed protein 2 antibody
  • heart and neural crest derivatives expressed transcript 2 antibody
  • Heart- and neural crest derivatives-expressed protein 2 antibody
  • Hed antibody
  • Highly similar to dHAND M musculus antibody
  • MGC125303 antibody
  • MGC125304 antibody
  • Th 2 antibody
  • Th2 antibody
  • Thing 2 antibody
  • Thing2 antibody
see all

Anti-HAND2 antibody images:

  Western blot - HAND2 antibody (ab10131)

Western blot - HAND2 antibody (ab10131)



Predicted band size : 26 kDa


ab10131 at 1/1000 dilution staining approximately 24kDa band of human HAND2 in HeLa whole cell lysate by Western blot (ECL).

References for Anti-HAND2 antibody (ab10131)

ab10131 has not yet been referenced specifically in any publications.

Publishing research using ab10131? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"