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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> HLH
Overview
Product name
Anti-HAND2 antibody
See all HAND2 products (3) ...
Description
Rabbit polyclonal to HAND2
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Chicken, Zebrafish
Immunogen
Synthetic peptide conjugated to KLH, corresponding to a region between amino acids 190-204 of Human HAND2.
Positive control
HeLa whole cell lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS, Sucrose
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Heart >> Hypertrophy >> Transcription factors
Cardiovascular >> Heart >> Cardiogenesis >> Transcription factors/regulators
Neuroscience >> Neurology process >> Neurogenesis
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> HLH
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Western blot - HAND2 antibody (ab10131)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab10131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: 1/1000. Detects a band of approximately 24 kDa (predicted molecular weight: 26 kDa).
ELISA: positive result with immunising peptide.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Tissue specificity
Heart.
Sequence similarities
Contains 1 basic helix-loop-helix (bHLH) domain.
Developmental stage
Expressed in the fetal heart.
Cellular localization
Nucleus.
Target information above from: UniProt accessionP61296
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- autonomic nervous system and neural crest derivatives-expressed protein 2 antibody
- heart antibody
- AI225906 antibody
see all
Database links
- Entrez Gene: 9464 Human
- Entrez Gene: 15111 Mouse
- Entrez Gene: 64637 Rat
- Entrez Gene: 58150 Zebrafish
- Omim: 602407 Human
- SwissProt: Q90690 Chicken
- SwissProt: P61296 Human
- SwissProt: Q61039 Mouse
see all
Anti-HAND2 antibody images:
Western blot - HAND2 antibody (ab10131)
Predicted band size : 26 kDa
ab10131 at 1/1000 dilution staining approximately 24kDa band of human HAND2 in HeLa whole cell lysate by Western blot (ECL).
References for Anti-HAND2 antibody (ab10131)
ab10131 has not yet been referenced specifically in any publications.
Publishing research using ab10131? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"