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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> HLH
Overview
Product name
Anti-HAND2 antibody
See all HAND2 products (3) ...
Description
Mouse monoclonal to HAND2
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant fragment: LSKIKTLRLA TSYIAYLMDL LAKDDQNGEA EAFKAEIKKT DVKEEKRKKE LNEILKSTVS SNDKKTKGRT GWPQHVWALE LK, corresponding to amino acids 135-217 of Human HAND2
LSKIKTLRLA TSYIAYLMDL LAKDDQNGEA EAFKAEIKKT DVKEEKRKKE LNEILKSTVS SNDKKTKGRT GWPQHVWALE LK
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG2a
Light chain type
kappa
Research areas
Cardiovascular >> Heart >> Hypertrophy >> Transcription factors
Cardiovascular >> Heart >> Cardiogenesis >> Transcription factors/regulators
Neuroscience >> Neurology process >> Neurogenesis
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> HLH
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Western blot - HAND2 antibody (ab56590)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56590 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 5 µg/ml.(This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.)
Target
Function
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.
Tissue specificity
Heart.
Sequence similarities
Contains 1 basic helix-loop-helix (bHLH) domain.
Developmental stage
Expressed in the fetal heart.
Cellular localization
Nucleus.
Target information above from: UniProt accessionP61296
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- autonomic nervous system and neural crest derivatives-expressed protein 2 antibody
- heart antibody
- AI225906 antibody
see all
Database links
- Entrez Gene: 9464 Human
- Omim: 602407 Human
- SwissProt: P61296 Human
- Unigene: 388245 Human
Anti-HAND2 antibody images:
Western blot - HAND2 antibody (ab56590)
Western blot against tagged recombinant protein immunogen using ab56590 HAND2 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa
References for Anti-HAND2 antibody (ab56590)
ab56590 has not yet been referenced specifically in any publications.
Publishing research using ab56590? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"