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Products:Cell Biology >> Apoptosis >> Mitochondrial
Overview
Product name
Anti-HAX1 antibody
See all HAX1 products (4) ...
Description
Rabbit polyclonal to HAX1
Specificity
At least four isoforms of HAX1 are known to exist. ab78939 is expected to recognize the longest isoform (HAX1a) as well as the shortest.
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
A 15 amino acid synthetic peptide near the amino terminus of human HAX1.
Positive control
Human Brain Tissue Lysate
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
ab78939 was purified by affinity chromatography via a peptide column
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> RNA Processing >> Other
Cell Biology >> Apoptosis >> Mitochondrial
Applications
Show applications key
Our Abpromise guarantee covers the use of ab78939 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 - 2 µg/ml.Predicted molecular weight: 32 kDa.
ELISA: Use at an assay dependent dilution.
Target
Relevance
HAX1 associates with HS1, binding to its N-terminal region. It is also known to associate with PKD2 (involved in polycystic kidney disease) and with cortactin/EMS1. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.
Cellular localization
Endoplasmic reticulum, Mitochondrial and Nuclear membrane. Note: Predominantly mitochondrial, but also to a lesser extent in endoplasmic reticulum and nuclear envelope.
Alternative names
- FLJ17042 antibody
- FLJ18492 antibody
- FLJ93803 antibody
see all
Database links
- Entrez Gene: 10456 Human
- Entrez Gene: 23897 Mouse
- Entrez Gene: 291202 Rat
- Omim: 605998 Human
- SwissProt: O00165 Human
- SwissProt: O35387 Mouse
- SwissProt: Q7TSE9 Rat
- Unigene: 199625 Human
References for Anti-HAX1 antibody (ab78939)
ab78939 has not yet been referenced specifically in any publications.
Publishing research using ab78939? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"