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Overview

  • Product nameAnti-HB9/HLXB9 antibodySee all HB9/HLXB9 primary antibodies ...
  • Description
    Sheep polyclonal to HB9/HLXB9
  • SpecificityThe antibody is specific for HB9 in Human and Mouse. This has been confirmed by Immunohistochemical analysis of Normal Term and First Trimester Human Placenta as well as western blot analysis of mouse Neuroblastoma and Spinal Cord cells (NSC-34).
  • Tested applicationsIHC-P, ELISA, WB more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide: H-APADRLRAESPSPPRLLAAHC-NH2 conjugated to Blue Carrier Protein, corresponding to amino acids 68-88 of Human HB9/HLXB9

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlNormal Term and First Trimester Human Placenta and Mouse Neuroblastoma and Spinal Cord cells (NSC-34).

Properties

Applications

Our Abpromise guarantee covers the use of ab64058 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P IHC-P: Use at an assay dependent dilution.
ELISA ELISA: 1/200 - 1/2600.
WB WB: 1/400. Predicted molecular weight: 41 kDa.

Target

  • FunctionPutative transcription factor involved in pancreas development and function.
  • Tissue specificityExpressed in lymphoid and pancreatic tissues.
  • Involvement in diseaseDefects in MNX1 are a cause of Currarino syndrome (CURRAS) [MIM:176450]. The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.
  • Sequence similaritiesContains 1 homeobox DNA-binding domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession P50219 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        HB 9 antibodyHB9 antibodyHLXB 9 antibody
        HLXB9 antibodyHomeo box HB9 antibodyHomeobox HB9 antibodyHomeobox protein HB9 antibodyHOXHB9 antibodyMNX1 antibodyMNX1_HUMAN antibodyMotor neuron and pancreas homeobox protein 1 antibodySacral agenesis autosomal dominant (Currarino triad) antibodySCRA 1 antibodySCRA1 antibody
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    References for Anti-HB9/HLXB9 antibody (ab64058)

    ab64058 has not yet been referenced specifically in any publications.

    Publishing research using ab64058 ? Please let us know so that we can cite the reference in this datasheet

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    Immunohistochemistry (Frozen sections) abreview for Anti-HB9/HLXB9 antibody

     Below Average
    Abreviews
    Application Immunohistochemistry (Frozen sections)
    Sample Mouse Tissue sections (Spinal cord at embryonic day e12.5)
    Specification Spinal cord at embryonic day e12.5
    Fixative Paraformaldehyde
    Permeabilization No
    Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 10% · Temperature: 20°C
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    Submitted Apr 20 2010

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"