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Anti-HBXIP antibody (ab66258)

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Overview

Product name

Anti-HBXIP antibody
See all HBXIP products (2) ...

Description

Mouse polyclonal to HBXIP

Tested applications

WB, ELISAmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein (Human) with tag.

Positive control

Full length recombinant HBXIP with tag.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 50% Glycerol, Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

  • Western blot - HBXIP antibody (ab66258)Western blot - HBXIP antibody (ab66258) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab66258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

ELISA: Use at an assay dependent dilution.
WB: 1/1000 - 1/2500. Predicted molecular weight: 10 kDa.

This antibody has only been tested in WB against the recombinant protein used as immunogen. We have no data on the detection of endogenous protein.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Tissue specificity

Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

Sequence similarities

Belongs to the HBXIP family.

Post-translational
modifications

Phosphorylated upon DNA damage, probably by ATM or ATR.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionO43504 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • HBV X interacting protein antibody
  • HBV X-interacting protein antibody
  • HBX interacting protein antibody
  • HBX-interacting protein antibody
  • hbxip antibody
  • HBXIP_HUMAN antibody
  • Hepatitis B virus X interacting protein antibody
  • Hepatitis B virus X-interacting protein antibody
  • MGC71071 antibody
  • XIP antibody
see all

Anti-HBXIP antibody images:

  Western blot - HBXIP antibody (ab66258)

Western blot - HBXIP antibody (ab66258)



Predicted band size : 10 kDa


Western blot against tagged recombinant protein immunogen using ab66258 HBXIP antibody at 1/1000 dilution. Predicted band size of immunogen is 36 kDa.

References for Anti-HBXIP antibody (ab66258)

ab66258 has not yet been referenced specifically in any publications.

Publishing research using ab66258? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"