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Products:Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Inhibitors
Overview
Product name
Anti-HBXIP antibody
See all HBXIP products (2) ...
Description
Mouse polyclonal to HBXIP
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein (Human) with tag.
Positive control
Full length recombinant HBXIP with tag.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, Whole serum
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Immune System Diseases >> Antiviral Signaling
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Inhibitors
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Western blot - HBXIP antibody (ab66258)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab66258 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
ELISA
Application notes
ELISA: Use at an assay dependent dilution.
WB: 1/1000 - 1/2500. Predicted molecular weight: 10 kDa.
This antibody has only been tested in WB against the recombinant protein used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
Tissue specificity
Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.
Sequence similarities
Belongs to the HBXIP family.
Post-translational
modifications
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionO43504
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- HBV X interacting protein antibody
- HBV X-interacting protein antibody
- HBX interacting protein antibody
see all
Database links
- Entrez Gene: 10542 Human
- NCBI: NP_006393 Human
- Omim: 608521 Human
- SwissProt: O43504 Human
- Unigene: 439815 Human
Anti-HBXIP antibody images:
Western blot - HBXIP antibody (ab66258)
Predicted band size : 10 kDa
Western blot against tagged recombinant protein immunogen using ab66258 HBXIP antibody at 1/1000 dilution. Predicted band size of immunogen is 36 kDa.
References for Anti-HBXIP antibody (ab66258)
ab66258 has not yet been referenced specifically in any publications.
Publishing research using ab66258? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"