You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAnti-HDAC1 antibodySee all HDAC1 primary antibodies ...
  • Description
    Mouse monoclonal to HDAC1
  • Tested applicationsWB, IHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-483 of Human HDAC1

Properties

Applications

Our Abpromise guarantee covers the use of ab55094 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.
    • Tissue specificityUbiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.
    • Sequence similaritiesBelongs to the histone deacetylase family. HD type 1 subfamily.
    • Post-translational
      modifications      Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.
      Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.
      Ubiquitinated by CHFR, leading to its degradation by the proteasome.
    • Cellular localizationNucleus.

      • Target information above from: UniProt accession Q13547 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          DKFZp686H12203 antibodyGON 10 antibodyHD1 antibody
          HDAC 1 antibodyHDAC1 antibodyHDAC1_HUMAN antibodyHistone deacetylase 1 antibodyReduced potassium dependency yeast homolog like 1 antibodyRPD3 antibodyRPD3L1 antibody
        see all

      Anti-HDAC1 antibody images

      • IHC-P - HDAC1 antibody (ab55094)
        IHC-P - HDAC1 antibody (ab55094)
        HDAC1 antibody (ab55094) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human liver.
      • Western blot - HDAC1 antibody (ab55094)
        Western blot - HDAC1 antibody (ab55094)


        Predicted band size : 55 kDa
        HDAC1 antibody (ab55094) at 1ug/lane + HeLa cell lysate at 25ug/lane.

      References for Anti-HDAC1 antibody (ab55094)

      ab55094 has not yet been referenced specifically in any publications.

      Publishing research using ab55094 ? Please let us know so that we can cite the reference in this datasheet

      Product Wall

      Submit an Abreview for ab55094 Submit a Question for ab55094

      There are currently no Abreviews or Questions for ab55094.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"