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Anti-HDAC10 antibody (ab18971)

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Overview

Product name

Anti-HDAC10 antibody
See all HDAC10 products (7) ...

Description

Rabbit polyclonal to HDAC10

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide, corresponding to amino acids near the N terminus of Human HDAC10.

Positive control

Jurkat Cells, Mouse Intestine and Rat Brain for Western blot.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Thimerosal (merthiolate).
Constituents: 50% Glycerol, 1% BSA, PBS.

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HDACs >> Class I
Stem Cells >> Signaling Pathways >> Wnt >> HDACs
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation

  • Western blot - HDAC10 antibody (ab18971)Western blot - HDAC10 antibody (ab18971) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab18971 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: Use at a concentration of 1 - 4 µg/ml. Detects a band of approximately 74 kDa (predicted molecular weight: 71 kDa). A 55 kDa band can also be detected in mouse and rat tissue lysate.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Tissue specificity

Ubiquitous. High expression in liver, spleen, pancreas and kidney.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Cellular localization

Cytoplasm. Nucleus. Excluded from the nucleoli.

Target information above from: UniProt accessionQ969S8 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DKFZP761B039 antibody
  • HD 10 antibody
  • HD10 antibody
  • HDA10_HUMAN antibody
  • HDAC 10 antibody
  • Hdac10 antibody
  • Histone deacetylase 10 antibody
  • MGC149722 antibody
  • OTTHUMP00000028555 antibody
see all

Database links

see all

Anti-HDAC10 antibody images:

  Western blot - HDAC10 antibody (ab18971)

Western blot - HDAC10 antibody (ab18971)

All lanes : Anti-HDAC10 antibody (ab18971) at 2.5 µg/ml

Lane 1 : Jurkat cell lysate (30ug)
Lane 2 : Mouse intestine lysate (30ug)
Lane 3 : Rat brain lysate (30ug)


Predicted band size : 71 kDa
Observed band size : 74 kDa (why is the actual band size different from the predicted?)
Additional bands at : 55 kDa. We are unsure as to the identity of these extra bands.

References for Anti-HDAC10 antibody (ab18971)

ab18971 has not yet been referenced specifically in any publications.

Publishing research using ab18971? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"