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Anti-HDAC3 antibody - ChIP Grade (ab96005)

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Overview

Product name

Anti-HDAC3 antibody - ChIP Grade
See all HDAC3 products (13) ...

Description

Rabbit polyclonal to HDAC3 - ChIP Grade

Tested applications

WB, IP, ChIPmore details

Cross reactivity

Reacts with

Human

Immunogen

GST fusion of the full-length human HDAC3.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Tissue culture supernatant

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Lipid and lipoprotein metabolism >> Lipid metabolism
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Epigenetics and Nuclear Signaling >> ChIP'ing antibodies >> ChIP'ing antibodies
Cardiovascular >> Heart >> Hypertrophy >> Other
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation >> HDACs >> Class I
Stem Cells >> Signaling Pathways >> Wnt >> HDACs
Epigenetics and Nuclear Signaling >> Chromatin Modifying Enzymes >> Acetylation

  • Western blot - HDAC3 antibody (ab96005)Western blot - HDAC3 antibody (ab96005) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab96005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Tissue specificity

Widely expressed.

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Post-translational
modifications

Sumoylated in vitro.

Cellular localization

Nucleus.

Target information above from: UniProt accessionO15379 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • RPD3 2 antibody
  • HD3 antibody
  • HDAC 3 antibody
  • HDAC3 antibody
  • HDAC3_HUMAN antibody
  • histone deacetylase 3 antibody
  • RPD3 antibody
  • RPD3-2 antibody
  • SMAP45 antibody
see all

Database links

Anti-HDAC3 antibody - ChIP Grade images:

  Western blot - HDAC3 antibody (ab96005)

Western blot - HDAC3 antibody (ab96005)

Anti-HDAC3 antibody - ChIP Grade (ab96005) at 1/2000 dilution + HeLa

Predicted band size : 49 kDa
Observed band size : 49 kDa

References for Anti-HDAC3 antibody - ChIP Grade (ab96005)

ab96005 has not yet been referenced specifically in any publications.

Publishing research using ab96005? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"