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Overview

  • Product nameHDAC8 peptideSee all HDAC8 proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab18968 - HDAC8 antibody.

    • Properties

  • Purification notesThe peptide ab41710 is a crude desalted synthetic peptide, purity range from 60-80%.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab41710 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    Blocking
  • Application notesBL: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution. Predicted molecular weight: 42 kDa.

    The peptide is used for blocking the antibody activity of HDAC8. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37degC.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        CDA07HD 8HD8
        HDAC 8Hdac8HDAC8_HUMANHDACL 1HDACL1HDACL1Histone deacetylase 8Histone deacetylase 8Histone deacetylase like 1Histone deacetylase like 1RPD 3RPD3RPD3
      see all
  • FunctionResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.
  • Tissue specificityWeakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney.
  • Sequence similaritiesBelongs to the histone deacetylase family. HD type 1 subfamily.
  • Post-translational
    modifications    Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4.
  • Cellular localizationNucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

    • Target information above from: UniProt accession Q9BY41 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for HDAC8 peptide (ab41710)

    ab41710 has not yet been referenced specifically in any publications.

    Publishing research using ab41710 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"