You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameHEC1 peptideSee all HEC1 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 600 to the C-terminus of Human HEC1.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab35651 - HEC1 antibody.
  • Protein length642 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab35651.

    • Protein info

    • Alternative names
        HECHECHEC 1
        Highly Expressed in CancerHighly Expressed in CancerHighly expressed in cancer proteinHighly expressed in cancer rich in leucine heptad repeatsHsHec1hsNDC80Kinetochore Associated 2Kinetochore Associated 2Kinetochore associated protein 2Kinetochore protein Hec1Kinetochore protein NDC80 homologKinetochore-associated protein 2KNTC 2KNTC2KNTC2NDC 80NDC80NDC80 homolog kinetochore complex componentNDC80 kinetochore complex component homologNDC80_HUMANRetinoblastoma associated protein HECRetinoblastoma-associated protein HECTID3
      see all
  • FunctionActs as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
  • Sequence similaritiesBelongs to the NDC80/HEC1 family.
  • Developmental stageExpression peaks in mitosis.
  • Post-translational
    modifications    Phosphorylation begins in S phase of the cell cycle and peaks in mitosis. Phosphorylated by NEK2. May also be phosphorylated by AURKA and AURKB.
  • Cellular localizationNucleus. Chromosome > centromere > kinetochore. Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore.

    • Target information above from: UniProt accession O14777 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for HEC1 peptide (ab35706)

    ab35706 has not yet been referenced specifically in any publications.

    Publishing research using ab35706 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab35706 Submit a Question for ab35706

    There are currently no Abreviews or Questions for ab35706.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"