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Anti-HES6 antibody (ab66461)

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Overview

Product name

Anti-HES6 antibody
See all HES6 products (3) ...

Description

Rabbit polyclonal to HES6

Tested applications

IHC-P, WB, IHC-Frmore details

Cross reactivity

Reacts with

Human

Predicted to work with

Mouse, Rat

Immunogen

Synthetic peptide derived from the C-terminal of Human HES6

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Epigenetics and Nuclear Signaling >> Transcription >> Co-factors
Neuroscience >> Neurology process >> Neurogenesis
Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> HLH / Leucine Zipper >> HLH

Applications

Show applications key

Our Abpromise guarantee covers the use of ab66461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

HES6 is a transcription cofactor that iteself does not bind to DNA but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. It also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCFEA2/E47, allowing ASCL1 and TCFEA2 to upregulate transcription in its presence. HES6 appears to have novel functions in tumour and cancer cell lines, although these have not yet been elucidated fully.

Cellular localization

Nuclear

Alternative names

  • C HAIRY1 antibody
  • Hairy and enhancer of split 6 antibody
  • Transcription cofactor HES6 antibody

Database links

References for Anti-HES6 antibody (ab66461)

This product has been referenced in:

  • Haapa-Paananen Set al. HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation. Oncogene : (2011). ICC/IF; Human.Read more (PubMed: 21785461) »
  • Qi Jet al. Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors. Cancer Cell 18:23-38 (2010). IHC; Human.Read more (PubMed: 20609350) »

See all 2 publications for this product

Publishing research using ab66461? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"