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Western blot - HEXA antibody (ab70083)
(enlarge)
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Product Name
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HEXA antibody
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See all HEXA antibodies (2)...
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Product type
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Primary antibodies
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Description
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Mouse polyclonal to HEXA
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Immunogen
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Full length human HEXA protein (NP_000511.1)
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
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Recommended dilutions
WB: 1/500 - 1/1000. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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HEXA transfected 293T cell lysate.
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Cellular localization
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Lysosomal
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Research areas
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Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Tags & Cell Markers >> Subcellular Markers >> Organelles >> Lysosome
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Relevance
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HEXA (Hexosaminidase A) is responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity.
Defects in HEXA are the cause of Tay-Sachs disease (TSD); also known as GM2-gangliosidosis type I. TSD is an autosomal recessive lysosomal storage disorder that has an increased incidence among Ashkenazi Jews and French Canadians in eastern Quebec. GM2 ganglioside accumulates in the absence of HEXA activity, leading to neurodegeneration and, in the infantile form of TSD, death in early childhood. The disease exists in several phenotypes: infantile (most common and most severe), juvenile and adult (late onset).
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
Constituents: 1X PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this HEXA antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for HEXA antibody images, references, products related to ab70083 and other tools.
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HEXA antibody images:
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 Western blot - HEXA antibody (ab70083)
All lanes : HEXA antibody (ab70083) at 1/500 dilution
Lane 1 : HEXA transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size : 61 kDa
Observed band size : 61 kDa
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Search PubMed (MEDLINE) for references to HEXA
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HEXA antibody - more information
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Customer reviews (feedback) regarding HEXA antibody |
Customer FAQs regarding HEXA antibody |
Protocols for HEXA antibody |
Price and availability of products related to HEXA antibody |
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HEXA antibody - related products:
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HEXA antibody - other tools:
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Contact Abcam with a Technical Enquiry about HEXA antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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