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Products:Neuroscience >> Neurology process >> Neurogenesis
Overview
Product name
Anti-HGFA Inhibitor 2 antibody - Between KD1 and KD2
See all HGFA Inhibitor 2 products (5) ...
Description
Rabbit polyclonal to HGFA Inhibitor 2 - Between KD1 and KD2
Specificity
This antibody is specific for HGFA Inhibitor 2. It will not recognize HGFA Inhibitor 1.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide based on the human HGFA Inhibitor 2 sequence. (Peptide available as ab41272.)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
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Western blot - HGFA Inhibitor 2 antibody - Between KD1 and KD2 (ab28334)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab28334 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT and 1/5000 for chemiluminescent substrates. Detects a band of approximately 22-32 kDa due to post-translational modifications (predicted molecular weight: 28 kDa). Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Tissue specificity
Expressed in placenta, kidney, pancreas, prostate, testis, thymus, and trachea.
Involvement in disease
Defects in SPINT2 are the cause of diarrhea type 3 (DIAR3) [MIM:270420]; also known as congenital sodium diarrhea (CSD). DIAR3 is a rare, inherited diarrhea of infancy. A diagnosis of DIAR3 is made on the findings of a life-threatening secretory diarrhea, severe metabolic acidosis, and hyponatremia secondary to extraordinarily high fecal losses of sodium, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune, and endocrine causes.
Sequence similarities
Contains 2 BPTI/Kunitz inhibitor domains.
Domain
This inhibitor contains two inhibitory domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionO43291
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AL024025 antibody
- Bikunin, placental antibody
- C76321 antibody
see all
Database links
- Entrez Gene: 10653 Human
- Omim: 605124 Human
- SwissProt: O43291 Human
- Unigene: 31439 Human
Anti-HGFA Inhibitor 2 antibody - Between KD1 and KD2 images:
Western blot - HGFA Inhibitor 2 antibody - Between KD1 and KD2 (ab28334)
All lanes : Anti-HGFA Inhibitor 2 antibody - Between KD1 and KD2 (ab28334) at 1/1000 dilution
Lane 1 : HGFA Inhibitor 2 at 0.05 µg
Lane 2 : HGFA Inhibitor 2 at 0.01 µg
Lane 3 : HGFA Inhibitor 2 at 0.001 µg
Predicted band size : 28 kDa
Observed band size : 23,32 kDa (why is the actual band size different from the predicted?)
Additional bands at : 58 kDa (possible dimer).
Protocols
References for Anti-HGFA Inhibitor 2 antibody - Between KD1 and KD2 (ab28334)
ab28334 has not yet been referenced specifically in any publications.
Publishing research using ab28334? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"