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Product Name
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HGFA Inhibitor 2 peptide (Between KD1 and KD2)
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide HGFA Inhibitor 2.
This peptide was used as an immunogen for ab28334 - HGFA Inhibitor 2 antibody - Between KD1 and KD2.
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Specificity
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We have a range of domain specific antibodies for this target. For a full list please see all HGFA Inhibitor 2 antibodies
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Tested applications
(see key)
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ELISA, WB
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. This peptide can be used with studies using ab28334. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Developmental Biology >> Reproduction >> Placental development
Cell Biology >> Proteolysis / Ubiquitin >> Protease inhibitors >> Serine protease inhibitors >> HAIs
Neuroscience >> Neurology process >> Neurogenesis
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Relevance
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HGFA Inhibitor 2 is an endogenous inhibitor of the kunitz-type serine proteinase HGF-activator (HGFA). HGF was first described as a hepatocyte-specific mitogen and survival factor, and has since been shown to exert a variety of actions on many cell types by binding to its MET receptor. HGF is activated by cleavage of the single-chain form to form a two-chain version by HGFA. HGFA Inhibitor 2 also inhibits trypsin, and MTSP-1 (Matriptase-1), a serine proteinase that also activates HGF, and HGF-2 has been shown to inhibit hepsin with nanamolar kIs. HGFA Inhibitor 2 was first known as bikunin, and SPINT2 (Serine Proteinase Inhibitor-2), a proteinase inhibitor found in amniotic fluid.
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HGFA Inhibitor 2 peptide (Between KD1 and KD2) (ab41272) |
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Purity
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>95% by SDS-PAGE
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Storage buffer
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Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride, pH 6.75
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this HGFA Inhibitor 2 peptide (Between KD1 and KD2) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to HGFA Inhibitor 2
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