![Immunohistochemistry - HHV8 antibody [LN35] (ab4103) image](#ab4103_1.jpg)
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Products:Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> HHV
Overview
Product name
Anti-HHV8 antibody [LN35]
Description
Rat monoclonal [LN35] to HHV8
Specificity
HHV 8 is the likely etiological agent of Kaposi’s sarcoma (KS). HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity.
Tested applications
IHC-P, IHC-Frmore details
Cross reactivity
Human Herpes virus 8
Immunogen
Recombinant protein corresponding to the latent nuclear antigen 1 molecule of HHV 8.
Epitope
Located within the ORF-73 region.
Positive control
Kaposi’s sarcoma.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 1% BSA, Tissue culture supernatant
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
LN35
Isotype
IgG2c
Research areas
Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> HHV
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Immunohistochemistry - HHV8 antibody [LN35] (ab4103)
![Immunohistochemistry - HHV8 antibody [LN35] (ab4103) image](/ps/datasheet/Images/4/ab4103/ab4103_1.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab4103 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/25 - 1/50.Perform heat mediated antigen retrieval before commencing with IHC staining protocol.(ABC method.)
IHC-Fr: 1/25 - 1/50.(ABC method.)
Target
Relevance
HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.
Alternative names
- HHV 8 antibody
- Human Herpes Virus 8 antibody
- Human herpesvirus 8 antibody
see all
Anti-HHV8 antibody [LN35] images:
Immunohistochemistry - HHV8 antibody [LN35] (ab4103)
Cultured cells infected with HHV8, stained with HHV8 using ABC and DAB chromogen.
References for Anti-HHV8 antibody [LN35] (ab4103)
This product has been referenced in:
- Loddenkemper Cet al. [The morphologic variants of KSHV/HHV 8-associated lymphoproliferations.] Pathologe : (2006).Read more (PubMed: 17160657) »
See 1 publication for this product
Publishing research using ab4103? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"