Overview
Product nameHIV gp41 L proteinSee all HIV gp41 L proteins and peptides ...
Protein descriptionThis recombinant protein contains the HIV immunodominant regions from gp41 (HIVgp41).
Expression hostE. coli
Properties
Purification notesPurified.
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab49071
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|
Application
|
Notes |
| ELISA |
ELISA: Use at an assay dependent dilution. |
| WB |
WB: Use at an assay dependent dilution. |
Protein info
RelevanceThe transmembrane protein gp41 (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Membranes fusion leads to delivery of the nucleocapsid into the cytoplasm.
Cellular localizationCell membrane
References for HIV gp41 L protein (ab49071)
ab49071
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
