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Overview

  • Product nameHIV1 gp41 proteinSee all HIV1 gp41 proteins and peptides ...
  • Protein descriptionHIV-1 env gp41 Strain IIIB is a non-glycosylated 288 amino acids polypeptide chain (a.a. 466-753) having a molecular mass of 32kDa. The protein is fused to B-galactosidase (114 kDa) at the N- terminus.
  • Expression hostE. coli

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Biological activityab68129 is immunoreactive with all sera of HIV1 infected individuals.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 8M Urea, 20mM PBS, 20mM Sodium chloride, 1mM DTT, pH 7.8
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab68129 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    WB WB: Use at an assay dependent dilution.
    ELISA ELISA: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        EnvEnv polyproteinEnvelope glycoprotein gp160
        Envelope Protein gp120Glycoprotein 41GP120gp41Human Immunodeficiency Virus 1Human Immunodeficiency Virus Type 1 gp41TMTransmembrane protein
      see all
  • Relevancegp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.

    • References for HIV1 gp41 protein (ab68129)

    This product has been referenced in:
    • Eissmann K  et al. HIV-1 fusion is blocked through binding of GB Virus C E2D peptides to the HIV-1 gp41 disulfide loop. PLoS One 8:e54452 (2013). ELISA . Read more (PubMed: 23349893) »

    See 1 Publication for this product

    Publishing research using ab68129 ? Please let us know so that we can cite the reference in this datasheet

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    Does this protein have a tag and waht is the expected mol weight that it should run at in a western blot?

    Thank you for contacting Abcam.

    I have heard back from the lab about ab68129 and I received the following product description: "ab68129 is a non-glycosylated 288 amino acids polypeptide chain (a.a. 466-753) having a molecular mass of 32kDa....

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    Our user would like to know the sequence of product ab68129(HIV1 gp41 protein). Is it possible to check the detail information?

    Unfortunately, the information you asked for is considered as proprietary know-how.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"