HLA DR + DP + DQ antibody [CR3/43.] (ab7856)

Product Name 

HLA DR + DP + DQ antibody [CR3/43.]

Product type 

Primary antibodies

Description 

Mouse monoclonal [CR3/43.] to HLA DR + DP + DQ

Immunogen 

Human Peripheral Blood Lymphocytes

Reacts with 
(species key)

Hu

Specificity 

The gene of the human histocompatibility complex class II consists of at least four subregions: HLADP,DQ, and DR, containing a minimum of one alpha and one beta chain. This antibody reacts with the beta-chain of all products of the gene subregions DP, DQ, and DR.

Tested applications 
(see key)

IHC-FoFr, IHC-Fr, IHC-P, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
Immunohistochemistry 1/50 - 1/100.
WB: 1/500. Detects a band of approximately 30 kDa (predicted molecular weight: 30 kDa).

Cellular localization 

Membrane; Single-pass type I membrane protein.

Research areas 

Immunology >> Adaptive Immunity >> MHC >> Class II

Relevance 

The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II.


This antibody principally labels B cells, interdigitating reticulum cells, Langerhans’ cells and manymacrophages.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

CR3/43.

Isotype 

IgG1

Light chain type 

kappa

Purity 

Tissue culture supernatant

Storage buffer 

20 mM tris-borate, 150 mM sodium chloride,0.1% sodium azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Store at +4°C. Do not freeze.

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