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Product Name
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HLA DR + DP + DQ antibody [WR18] (Phycoerythrin)
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See all HLA DR + DP + DQ antibodies (6)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [WR18] to HLA DR + DP + DQ (Phycoerythrin)
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Immunogen
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B-CLL cells (Human).
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Reacts with
(species key)
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Hu
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Specificity
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ab23901 recognises the common b unit of HLA-Class 2 molecules. Stains B cells, monocytes and activated T cells.
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Tested applications
(see key)
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Flow Cyt
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Abreviews
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Application notes
(see key)
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Recommended dilutions Flow Cyt: Use 10µl for 106 cells or 100ul whole blood.
Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; Single-pass type I membrane protein.
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Research areas
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Immunology >> Adaptive Immunity >> MHC >> Class II
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Relevance
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The major histocompatibility complex (MHC) is a large genomic region or gene family found in most vertebrates containing many genes with important immune system roles. In humans, the MHC spans almost 4 megabases of chromosome 6 and includes more than 200 known genes, of which about half have known immmunological functions. The best known genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. In humans, these genes are referred to as human leukocyte antigen (HLA) genes. The most intensely studied HLA genes are: HLA A, HLA B, HLA C, HLA DPA, HLA DPB1, HLA DQA1, HLA DQB1, HLA DRA, and HLA DRB1. In humans, the HLA is divided into three regions: Class I, II, and III. The A, B, and C genes belong to HLA class I while the six D genes belong to class II.
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Database links
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The links below go to external sites and will open in a new browser window
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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WR18
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Myeloma
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NS1
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Isotype
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IgG2a
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Purity
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Protein G purified
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Conjugation notes
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Purified IgG conjugated to R. Phycoerythrin (RPE)
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Storage buffer
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Preservative: 0.09% Sodium Azide Constituents: 0.1% BSA, PBS, pH 7.4 Material safety datasheet (MSDS) for this product: Sodium Azide MSDS
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Form
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Liquid
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Conjugation
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Phycoerythrin
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Concentration
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0.100 mg/ml
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Storage instructions
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Store at +4°C in the dark. Do not freeze.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this HLA DR + DP + DQ antibody [WR18] (Phycoerythrin) is on this datasheet. But please do contact us if you would like any reassurance! |
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References for HLA DR + DP + DQ antibody [WR18] (Phycoerythrin) (ab23901)
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This product has been used in:
Brignone C et al. A soluble form of lymphocyte activation gene-3 (IMP321) induces activation of a large range of human effector cytotoxic cells. J Immunol 179:4202-11 (2007). Flow Cyt; Human. PubMed: 17785860
If you publish research using ab23901 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to HLA DR + DP + DQ
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HLA DR + DP + DQ antibody [WR18] (Phycoerythrin) - more information
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HLA DR + DP + DQ antibody [WR18] (Phycoerythrin) - other tools:
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Contact Abcam with a Technical Enquiry about HLA DR + DP + DQ antibody [WR18] (Phycoerythrin) |
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