You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-HLA E antibody [MEM-E/06] (ab3984)

CodeSizePriceAbpointsAvailability
    
Add to basket
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-HLA E antibody [MEM-E/06]
See all HLA E products (8) ...

Description

Mouse monoclonal [MEM-E/06] to HLA E

Specificity

The antibody recognized native surface-expressed HLA E, but not denaturated heavy chain of HLA E. The published results showed that the antibody cross-reacts with some classical MHC Class I molecules (HLA A3, A11, B7). However, the recent Workshop I Session on the 3rd International Conference on HLA-G (Paris, July 2003) confirmed that the antibody exhibits much broader cross-reactivity classical MHC Class I antigens, namely with HLA A24, A32, B8, B15, B27, B35, B44, B54, C3, C4, C5 and C7.

Tested applications

Flow Cyt, IP, IHC-Pmore details

Cross reactivity

Reacts with

Human

Immunogen

Bacterially expressed recombinant full length protein refolded with beta2-microglobulin and peptide (Human).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4

Concentration

Concentration information loading...

Purity

>95% by SDS-PAGE

Purification notes

Purified from ascites by protein A affinity chromatography.

Clonality

Monoclonal

Clone number

MEM-E/06

Myeloma

unknown

Isotype

IgG1

Light chain type

unknown

Research areas

Immunology >> Adaptive Immunity >> MHC >> Class I

Applications

Show applications key

Our Abpromise guarantee covers the use of ab3984 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

HLA E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA E binds a restricted subset of peptides derived from the leader peptides of other class I molecules.

Cellular localization

Membrane; Single-pass type I membrane protein

Alternative names

  • HLA class I histocompatibility antigen E alpha chain antibody
  • DKFZp686P19218 antibody
  • EA1.2 antibody
  • EA2.1 antibody
  • HLA 6.2 antibody
  • HLA class I histocompatibility antigen alpha chain E antibody
  • HLA class I histocompatibility antigen E alpha chain precursor antibody
  • HLA-6.2 antibody
  • HLA6.2 antibody
  • HLAE antibody
  • Lymphocyte antigen antibody
  • Major histocompatibility complex class I E antibody
  • MHC antibody
  • MHC class I antigen E antibody
  • MHC HLA E alpha 1 antibody
  • MHC HLA E alpha 2.1 antibody
  • QA1 antibody
see all

Database links

References for Anti-HLA E antibody [MEM-E/06] (ab3984)

This product has been referenced in:

  • Menier Cet al. Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules. Hum Immunol 64:315-26 (2003).Read more (PubMed: 12590976) »

See 1 publication for this product

Publishing research using ab3984? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"