HMGA2 antibody (ab41878)

Product Name 

HMGA2 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to HMGA2

Immunogen 

Synthetic peptide corresponding to C-terminal region of human HMGA2. The amino acid sequence is unavailable.

Reacts with 
(species key)

Hu

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
WB: Use at a concentration of 2 - 4 µg/ml for 2 hours at RT. Predicted molecular weight: 12 kDa.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

SW579 cells. Colon carcinoma.

Cellular localization 

Nuclear

Research areas 

Developmental Biology >> Post embryonic development >> Aging
Cancer >> Cell cycle >> Cell differentiation
Stem Cells >> Neural Stem Cells >> Intracellular
Chromatin and Nuclear Signaling >> Cell cycle >> Cell Differentiation
Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Metabolism
Chromatin and Nuclear Signaling >> Histones >> HMGs
Neuroscience >> Cell Type Marker >> Neural Stem Cell marker

Relevance 

The HMGA2 protein is a member of the High Mobility Group (HMG) family of non-histone chromatin proteins. It is expressed exclusively during mammalian embryonic development and in some cancers. HMGA2 regulates chromatin structure and gene expression by binding AT-rich sequences near promoters, altering the conformation of the surrounding DNA and thus modulating the binding of other transcription factors at the promoter. The deletion, amplification, and rearrangement of this gene are associated with myxoid liposarcoma and suggest a role in adipogenesis and mesenchymal differentiation. A gene knock out study in mouse demonstrated that this gene is involved in diet-induced obesity. The expression of HMGA2 is high in neural stem cells, and decreases with age. HMG2A promotes fetal and young adult stem cell self-renewal by decreasing p16/INK4a and p19/ARF expression levels.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Store at +4°C.

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