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Immunocytochemistry/ Immunofluorescence - HMGA2 antibody (ab56390)
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Product Name
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HMGA2 antibody
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See all HMGA2 antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to HMGA2
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Immunogen
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Recombinant fragment: MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK KP, corresponding to amino acids 1-93 of Human HMGA2
BLAST 'MSARGEGAGQ PSTSAQGQPA APAPQKRGRG RPRKQQQEPT GEPSPKRPRG RPKGSKNKSP SKAAQKKAEA TGEKRPRGRP RKWPQQVVQK ' with  or 
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Reacts with
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Hu
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Tested applications
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ICC
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Abreviews
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Application notes
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Recommended dilutions
ICC: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Developmental Biology >> Post embryonic development >> Aging
Cancer >> Cell cycle >> Cell differentiation
Stem Cells >> Neural Stem Cells >> Intracellular
Chromatin and Nuclear Signaling >> Cell cycle >> Cell Differentiation
Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Metabolism
Chromatin and Nuclear Signaling >> Histones >> HMGs
Neuroscience >> Cell Type Marker >> Neural Stem Cell marker
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Relevance
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The HMGA2 protein is a member of the High Mobility Group (HMG) family of non-histone chromatin proteins. It is expressed exclusively during mammalian embryonic development and in some cancers. HMGA2 regulates chromatin structure and gene expression by binding AT-rich sequences near promoters, altering the conformation of the surrounding DNA and thus modulating the binding of other transcription factors at the promoter. The deletion, amplification, and rearrangement of this gene are associated with myxoid liposarcoma and suggest a role in adipogenesis and mesenchymal differentiation. A gene knock out study in mouse demonstrated that this gene is involved in diet-induced obesity. The expression of HMGA2 is high in neural stem cells, and decreases with age. HMG2A promotes fetal and young adult stem cell self-renewal by decreasing p16/INK4a and p19/ARF expression levels.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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Batch dependent within range: 0.50 - 1.00 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this HMGA2 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for HMGA2 antibody images, references, products related to ab56390 and other tools.
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HMGA2 antibody images:
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 Immunocytochemistry/ Immunofluorescence - HMGA2 antibody (ab56390)
ab56390 staining HMGA2 in HeLa cells.
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Search PubMed (MEDLINE) for references to HMGA2
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HMGA2 antibody - more information
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Customer reviews (feedback) regarding HMGA2 antibody |
Customer FAQs regarding HMGA2 antibody |
Protocols for HMGA2 antibody |
Price and availability of products related to HMGA2 antibody |
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HMGA2 antibody - related products:
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HMGA2 antibody - other tools:
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Contact Abcam with a Technical Enquiry about HMGA2 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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