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Products:Neuroscience >> Cell Type Marker >> Neural Stem Cell marker
Overview
Product name
Anti-HMGA2 antibody, prediluted
See all HMGA2 products (5) ...
Description
Rabbit polyclonal to HMGA2, prediluted
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse
Immunogen
Synthetic peptide corresponding to C-terminal of human HMGA2.
Positive control
SW579 cells and Breast carcinoma.
Properties
Form
Prediluted
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 50mM Tris, pH 7.6
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Developmental Biology >> Post embryonic development >> Aging
Cancer >> Cell cycle >> Cell differentiation
Stem Cells >> Neural Stem Cells >> Intracellular
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Differentiation
Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Metabolism
Epigenetics and Nuclear Signaling >> Histones >> HMGs
Neuroscience >> Cell Type Marker >> Neural Stem Cell marker
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HMGA2 antibody, prediluted (ab52089)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab52089 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution.
Target
Function
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2.
Involvement in disease
Note=A chromosomal aberration involving HMGA2 is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(3;12)(q27-q28;q13-q15) with LPP is shown in lipomas. HMGA2 is also fused with a number of other genes in lipomas.
Note=A chromosomal aberration involving HMGA2 is associated with pulmonary chondroid hamartomas. Translocation t(3;12)(q27-q28;q14-q15) with LPP is detected in pulmonary chondroid hamartomas.
Note=A chromosomal aberration involving HMGA2 is associated with parosteal lipomas. Translocation t(3;12)(q28;q14) with LPP is also shown in one parosteal lipoma.
Note=A chromosomal aberration involving HMGA2 is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with RAD51L1. Chromosomal rearrangements involving HMGA2 do not seem to be the principle pathobiological mechanism in uterine leiomyoma.
Sequence similarities
Belongs to the HMGA family.
Contains 3 A.T hook DNA-binding domains.
Developmental stage
Expressed predominantly during embryogenesis.
Post-translational
modifications
Regulated by cell cycle-dependent phosphorylation which alters its DNA binding affinity.
Cellular localization
Nucleus.
Target information above from: UniProt accessionP52926
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- HMGA 2 antibody
- BABL antibody
- High mobility group (nonhistone chromosomal) protein isoform I C antibody
see all
Database links
- Entrez Gene: 8091 Human
- Entrez Gene: 15364 Mouse
- Omim: 600698 Human
- SwissProt: P52926 Human
- SwissProt: P52927 Mouse
- Unigene: 505924 Human
- Unigene: 157190 Mouse
Anti-HMGA2 antibody, prediluted images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - HMGA2 antibody, prediluted (ab52089)
Staining of HMGA2 in human breast carcinoma by immunohistochemistry (formalin fixed, paraffin embedded section) using ab52089 (prediluted).
References for Anti-HMGA2 antibody, prediluted (ab52089)
ab52089 has not yet been referenced specifically in any publications.
Publishing research using ab52089? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"