Anti-HOMER3 antibody (ab97438)
Key features and details
- Rabbit polyclonal to HOMER3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-HOMER3 antibody -
Description
Rabbit polyclonal to HOMER3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 55 and 275 of HOMER3 (AAH12113).
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Positive control
- NT2D1 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab97438 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 40 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 40 kDa. |
Target
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Function
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. -
Sequence similarities
Belongs to the Homer family.
Contains 1 WH1 domain. -
Domain
The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. -
Cellular localization
Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > synapse. Postsynaptic density of neuronal cells. - Information by UniProt
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Database links
- Entrez Gene: 9454 Human
- Entrez Gene: 26558 Mouse
- Entrez Gene: 29548 Rat
- Omim: 604800 Human
- SwissProt: Q9NSC5 Human
- SwissProt: Q99JP6 Mouse
- SwissProt: Q9Z2X5 Rat
- Unigene: 720208 Human
see all -
Alternative names
- HOME3_HUMAN antibody
- HOMER 3 antibody
- Homer 3D protein antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab97438 has been referenced in 1 publication.
- Pu J et al. Long non-coding RNA HOMER3-AS1 drives hepatocellular carcinoma progression via modulating the behaviors of both tumor cells and macrophages. Cell Death Dis 12:1103 (2021). PubMed: 34815380