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Product Name
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HP1 alpha peptide
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide, , correlating to aa from within regions 1-40 and 40-90 (separated with a GG linker) of Human HP1 alpha.
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This peptide was used as an immunogen for ab9057 - HP1 alpha antibody - Heterochromatin marker and ab14298 - HP1 alpha antibody [mAbcam 14298].
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Tested applications
(see key)
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BL
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Application notes
(see key)
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Recommended dilutions
BL: Use at a concentration of 1 µg/ml.
This peptide can be used with studies using ab16482, ab9057 and ab14298.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Tags & Cell Markers >> Subcellular Markers >> Nucleus >> Chromatin
Chromatin and Nuclear Signaling >> Chromatin Binding Proteins >> Methyl Lysine
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Relevance
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HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane.
HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required
for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.
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Storage buffer
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Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride. pH 6.75
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Expression system
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CHO
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this HP1 alpha peptide is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for HP1 alpha peptide images, references, products related to ab4718 and other tools.
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HP1 alpha peptide images:
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Search PubMed (MEDLINE) for references to HP1 alpha
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HP1 alpha peptide - more information
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Customer reviews (feedback) regarding HP1 alpha peptide |
Customer FAQs regarding HP1 alpha peptide |
Protocols for HP1 alpha peptide |
Price and availability of products related to HP1 alpha peptide |
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HP1 alpha peptide - related products:
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HP1 alpha peptide - other tools:
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Contact Abcam with a Technical Enquiry about HP1 alpha peptide |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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