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Product Name
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HP1 gamma antibody
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See all HP1 gamma antibodies (10)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to HP1 gamma
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Immunogen
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Synthetic peptide corresponding to a region between residues 1 and 50 of human HP1 gamma (NP_009207.2).
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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IP
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: Use at 2-5µg/mg of lysate.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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HeLa whole cell lysate.
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Cellular localization
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Nuclear
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Research areas
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Chromatin and Nuclear Signaling >> Chromatin Binding Proteins >> Methyl Lysine
Chromatin and Nuclear Signaling >> Chromatin Binding Proteins >> Methylated DNA
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Relevance
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HP1 gamma appears to be involved in transcriptional silencing in heterochromatin-like complexes. It recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. HP1 gamma may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) and involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.09% Sodium Azide
Constituents: PBS, 8mM Phosphate, 60mM Citrate, 150mM Tris, pH 7-8 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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ab72041 was affinity purified using an epitope specific to HP1 gamma immobilized on solid support.
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this HP1 gamma antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to HP1 gamma
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HP1 gamma antibody - more information
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