Anti-HPV16 E2 antibody [TVG 261] (ab17185)
Key features and details
- Mouse monoclonal [TVG 261] to HPV16 E2
- Suitable for: ELISA, WB
- Reacts with: Human papillomavirus type 16
- Isotype: IgG1
Overview
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Product name
Anti-HPV16 E2 antibody [TVG 261]
See all HPV16 E2 primary antibodies -
Description
Mouse monoclonal [TVG 261] to HPV16 E2 -
Host species
Mouse -
Tested applications
Suitable for: ELISA, WBmore details -
Species reactivity
Reacts with: Human papillomavirus type 16 -
Immunogen
Vaccinia-E2 followed by intravenous injection of the maltose binding protein MBP-E2 (generated from an expression vector in which the E2 ORF was cloned in frame with malE).
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Epitope
aa2-17 - ETLCQRLNVCQDKILT. -
General notes
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication. TVG 261 is useful for detection of protein in cervical lesions.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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Purity
Protein A/G purified -
Primary antibody notes
The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. E1 and E2 are proteins involved in the regulation of viral DNA replication. TVG 261 is useful for detection of protein in cervical lesions. -
Clonality
Monoclonal -
Clone number
TVG 261 -
Myeloma
NS0/1 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab17185 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent dilution.
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WB | (2) |
Use at an assay dependent dilution. Predicted molecular weight: 42 kDa.
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Notes |
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ELISA
Use at an assay dependent dilution. |
WB
Use at an assay dependent dilution. Predicted molecular weight: 42 kDa. |
Target
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Alternative names
- HPV16 regulatory protein E2 antibody
- Human papilloma virus 16 E2 antibody
- Human papilloma virus 16 regulatory protein E2 antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (11)
ab17185 has been referenced in 11 publications.
- Prabhakar AT et al. CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle. mBio 12:e0116321 (2021). PubMed: 34544280
- Evans MR et al. Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle. J Virol 93:N/A (2019). PubMed: 30518656
- Ludwig S et al. Molecular and Functional Profiles of Exosomes From HPV(+) and HPV(-) Head and Neck Cancer Cell Lines. Front Oncol 8:445 (2018). PubMed: 30370252
- Yuan R et al. Cardioprotective Effects of HuoxueAnshen Recipe against Myocardial Injuries Induced by Sleep Deprivation in Rats. Evid Based Complement Alternat Med 2017:7359760 (2017). PubMed: 28479928
- Evans MR et al. An oral keratinocyte life cycle model identifies novel host genome regulation by human papillomavirus 16 relevant to HPV positive head and neck cancer. Oncotarget 8:81892-81909 (2017). WB . PubMed: 29137231