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Product name
Anti-HSC70 Interacting Protein HIP antibody [2G6]
See all HSC70 Interacting Protein HIP products (10) ...
Description
Mouse monoclonal [2G6] to HSC70 Interacting Protein HIP
Tested applications
IP, WBmore details
Cross reactivity
Reacts with
Rabbit, Chicken, Human
Immunogen
Recombinant full length protein (Human).
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.05% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
2G6
Isotype
IgG
Research areas
Signal Transduction >> Protein Trafficking >> Chaperones >> Heat Shock Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2813 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP
WB
Application notes
Immunoprecipitation: Assay dependent.
Western Blot: use at a concentration of 1 µg/ml.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
By Western blot, this antibody detects a 48 kDa protein representing Hip from rabbit reticulocyte lysate
Target
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
Sequence similarities
Belongs to the FAM10 family.
Contains 1 STI1 domain.
Contains 3 TPR repeats.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionP50502
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AAG 2 antibody
- AAG2 antibody
- Aging associated protein 2 antibody
see all
Database links
- Entrez Gene: 6767 Human
- Omim: 606796 Human
- SwissProt: P50502 Human
- Unigene: 712713 Human
References for Anti-HSC70 Interacting Protein HIP antibody [2G6] (ab2813)
This product has been referenced in:
- Prapapanich V et al. Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly. Mol Cell Biol 18:944-52 (1998).Read more (PubMed: 9447991) »
See 1 publication for this product
Publishing research using ab2813? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"