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Product name
Anti-HSC70 Interacting Protein HIP antibody
See all HSC70 Interacting Protein HIP products (10) ...
Description
Rabbit polyclonal to HSC70 Interacting Protein HIP
Specificity
This antibody detects both recombinant rat HSC70 Interacting Protein HIP as well as the native protein in tissue extracts.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Cow, Human
Immunogen
Recombinant Histidine 6 fusion protein (Rat).
General notes
For maximum product recovery, after thawing, centrifuge the product vial before removing cap.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 50% Glycerol, PBS, pH 7.2
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Protein Trafficking >> Chaperones >> Heat Shock Proteins
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Western blot - HSC70 Interacting Protein HIP antibody (ab13490)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab13490 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/5000. Detects a band of approximately 58 kDa (predicted molecular weight: 42 kDa).for human and bovine or 1/5000 for mouse and rat.
Target
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
Sequence similarities
Belongs to the FAM10 family.
Contains 1 STI1 domain.
Contains 3 TPR repeats.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionP50502
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AAG 2 antibody
- AAG2 antibody
- Aging associated protein 2 antibody
see all
Database links
- Entrez Gene: 281506 Cow
- Entrez Gene: 6767 Human
- Entrez Gene: 70356 Mouse
- Entrez Gene: 81800 Rat
- Omim: 606796 Human
- SwissProt: P50502 Human
- SwissProt: Q99L47 Mouse
- SwissProt: P50503 Rat
see all
Anti-HSC70 Interacting Protein HIP antibody images:
Western blot - HSC70 Interacting Protein HIP antibody (ab13490)
Anti-HSC70 Interacting Protein HIP antibody (ab13490) at 1/1000 dilution + Lysates prepared from rat testis tissue
Predicted band size : 42 kDa
References for Anti-HSC70 Interacting Protein HIP antibody (ab13490)
This product has been referenced in:
- Heldens L et al. Co-chaperones are limiting in a depleted chaperone network. Cell Mol Life Sci 67:4035-48 (2010). WB; Human.Read more (PubMed: 20556630) »
See 1 publication for this product
Publishing research using ab13490? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"